2024 CPT/HCPCS Codebook

eGuide

Enjoy our comprehensive codebook for 2024. Inside you’ll find all the CPT and HCPCS codes that are new, those that have been removed, and everything that’s been revised. You won’t find anything else like this for free. We simply want to help you improve your billing and coding.

Private practice healthcare billing and coding is always challenging. Keeping up with year-over-year changes can be just as daunting. Staying abreast of the medical codes for your specialty can have a big impact on your revenue cycle management and revenue collections performance. To help transform your billing and coding staff into financial rockstars, we compiled all the CPT and HCPCS code changes for 2024 and broke them down by specialty. We are offering this definitive 70-page billing and coding guide as a free, downloadable, and printable PDF.

Whether you are a practice with in-house billing staff or are an outsourced revenue cycle management company, this reference guide presents and explains what changes can impact you. It is organized and color-coded by specialty and code status. Get one free download of our exclusive 2024 billing and coding codebook emailed to your inbox. Bonus content added for requested specialties:

Occupational therapy
Psychiatry services and procedures
Evaluation and management coding (E&M)

We’ve also included bonus content for our customers:

2024 CPT and HCPCS code updates
Updating a charge slip with 2024 CPT and HCPCS changes
Updating form templates with 2024 CPT and HCPCS changes

CPT/HCPCS

Codes 2024

Added | Revised | Deleted

BONUS: ICD-10 Codes for 2024

ADDED/REVISED/DELETED CPT/HCPCS & ICD-10 CODES DISCLAIMER

ADVANCEDMD IS PROVIDING THIS CPT/HCPCS & ICD-10 LIST OF ADDED, REVISED AND DELETED CODES FOR 2024 “AS IS” WITHOUT WARRANTY OF ANY KIND, INCLUDING BUT NOT LIMITED TO ANY EXPRESSED OR IMPLIED WARRANTIES OR WARRANTIES FOR FITNESS FOR A PARTICULAR PURPOSE OR MERCHANTABILITY. ADVANCEDMD DISCLAIMS RESPONSIBILITY FOR ANY ERRORS OR OMISSIONS CONTAINED WITHIN THE ADDED, REVISED AND DELETED CPT/HCPCS & ICD-10 CODES LIST INCLUDING IN CONJUNCTION WITH ITS USE WITH ANY SOFTWARE AND/OR HARDWARE SYSTEM. ADVANCEDMD DISCLAIMS RESPONSIBILITY FOR ANY CONSEQUENCES OR LIABILITY WHICH MAY BE ATTRIBUTED TO

OR RELATED IN ANY WAY TO THE USE, NON-USE OR INTERPRETATION OF THE INFORMATION PROVIDED OR NOT PROVIDED WITHIN THIS DOCUMENT. THE INFORMATION PROVIDED WITHIN THIS DOCUMENT IS SOLELY AS A SERVICE TO ADVANCEDMD CLIENTS AND IS NOT A GUARANTEE OF ANY TYPE AS TO THE ACCURACY OR COMPLETENESS OF THE INFORMATION. WE CANNOT GUARANTEE THE ACCURACY OF THE INFORMATION PRINTED HEREIN AND ARE NOT RESPONSIBLE FOR CLAIMS OR LIABILITY THAT MAY RESULT FROM THE USE OF THIS INFORMATION.

ADVANCEDMD NEITHER REPRESENTS NO GUARANTEES THAT ANY OF THE LIST OF CPT/HCPCS & ICD-10 CODES INFORMATION CONTAINED HEREIN IS COMPLETE, ACCURATE OR APPLICABLE TO ANY SPECIFIC CLIENT OR THEIR PRACTICE OR PATIENT(S) AND ADVANCEDMD DISCLAIMS ALL LIABILITY FOR ANY CONSEQUENCES WHICH MAY RESULT FROM RELIANCE ON THE INFORMATION CONTAINED WITHIN THIS DOCUMENT. THIS INFORMATION IS NOT INTENDED TO BE NOR SHOULD BE CONSTRUED AS LEGAL ADVICE OR GUIDANCE IN ANY MANNER OR CAPACITY, CLIENTS ARE RESPONSIBLE FOR DETERMINING WHETHER THE INFORMATION CONTAINED WITHIN THIS DOCUMENT IS USEFUL OR APPLICABLE FOR

THEIR PURPOSES. THIS INFORMATION IS NOT INTENDED TO BE A FINAL OR EXHAUSTIVE LIST OF ADDED, REVISED AND DELETED CODES FOR 2024, THE CPT/HCPCS CODES ARE FREQUENTLY REVISED AND ADVANCEDMD DISCLAIMS ALL RESPONSIBILITY FOR ADDED, REVISED AND DELETED CODES WHICH ARE LATER ADDED, REVISED, MODIFIED OR DELETED AT ANY TIME; NO INDEPENDENT VERIFICATION OF THE DATA IS CLAIMED OR IMPLIED.

FURTHERMORE, PLEASE NOTE THAT ADVANCEDMD IS PROVIDING THIS INFORMATION WITHIN ITS LIMITED LICENSE WITH THE AMERICAN MEDICAL ASSOCIATION (AMA) AND THAT ANY QUESTIONS PERTAINING TO LICENSE OR USE OF THE CPT MUST BE ADDRESSED TO THE AMA AS THE SCOPE OF ADVANCEDMD’S LICENSE IS DETERMINED BY THE AMA, THE COPYRIGHT HOLDER. CLIENTS DO NOT ACT FOR OR ON BEHALF OF ADVANCEDMD AND ADVANCEDMD SPECIFICALLY DISCLAIMS REASONABILITY FOR ANY LIABILITY ATTRIBUTABLE TO THE CLIENT’S USE OF THE CPT/HCPCS CODES. IN NO EVENT SHALL ADVANCEDMD BE LIABLE FOR DIRECT, INDIRECT, SPECIAL, INCIDENTAL, OR CONSEQUENTIAL DAMAGES ARISING OUT OF THE USE OF SUCH INFORMATION OR MATERIAL.

Helpful Tips

Here are some helpful articles to assist you in updating these codes in AdvancedMD. You must be logged into your office key to access these articles below.

Annual CPT / HCPCS Code Updates

Updating a Charge Slip with annual CPT/HCPCS changes Updating Form Templates with annual CPT/HCPCS changes

2024 CPT Codes

Below are the 2024 CPT code updates. This list includes new CPT codes, revised codes and deleted codes.

Added CPT Codes for 2024

Speciality

CPT Code

Description

Proprietary Laboratory Analyses

Proprietary Laboratory Analyses	0420U	Oncology (urothelial), mRNA expression profiling by real-time quantitative PCR of MDK, HOXA13, CDC2, IGFBP5, and CXCR2 in combination with droplet digital PCR (ddPCR) analysis of 6 single-nucleotide polymorphisms (SNPs) genes TERT and FGFR3, urine, algorithm reported as a risk score for urothelial carcinoma
Proprietary Laboratory Analyses	0421U	Oncology (colorectal) screening, quantitative real-time target and signal amplification of 8 RNA markers (GAPDH, SMAD4, ACY1, AREG, CDH1, KRAS, TNFRSF10B, EGLN2) and fecal hemoglobin, algorithm reported as a positive or negative for colorectal cancer risk
Proprietary Laboratory Analyses	0422U	Oncology (pan-solid tumor), analysis of DNA biomarker response to anti-cancer therapy using cell-free circulating DNA, biomarker comparison to a previous baseline pre-treatment cell-free circulating DNA analysis using next-generation sequencing, algorithm reported as a quantitative change from baseline, including specific alterations, if appropriate
Proprietary Laboratory Analyses	0423U	Psychiatry (eg, depression, anxiety), genomic analysis panel, including variant analysis of 26 genes, buccal swab, report including metabolizer status and risk of drug toxicity by condition
Proprietary Laboratory Analyses	0424U	Oncology (prostate), exosome-based analysis of 53 small noncoding RNAs (sncRNAs) by quantitative reverse transcription polymerase chain reaction (RT-qPCR), urine, reported as no molecular evidence, low-, moderate- or elevated-risk of prostate cancer
Proprietary Laboratory Analyses	0425U	Genome (eg, unexplained constitutional or heritable disorder or syndrome), rapid sequence analysis, each comparator genome (eg, parents, siblings)
Proprietary Laboratory Analyses	0426U	Genome (eg, unexplained constitutional or heritable disorder or syndrome), ultra-rapid sequence analysis
Proprietary Laboratory Analyses	0427U	Monocyte distribution width, whole blood (List separately in addition to code for primary procedure)
Proprietary Laboratory Analyses	0428U	Oncology (breast), targeted hybrid-capture genomic sequence analysis panel, circulating tumor DNA (ctDNA) analysis of 56 or more genes, interrogation for sequence variants, gene copy number amplifications, gene rearrangements, microsatellite instability, and tumor mutation burden
Proprietary Laboratory Analyses	0429U	Human papillomavirus (HPV), oropharyngeal swab, 14 high-risk types (ie, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68)
Proprietary Laboratory Analyses	0430U	Gastroenterology, malabsorption evaluation of alpha-1-antitrypsin, calprotectin, pancreatic elastase and reducing substances, feces, quantitative
Proprietary Laboratory Analyses	0431U	Glycine receptor alpha1 IgG, serum or cerebrospinal fluid (CSF), live cell-binding assay (LCBA), qualitative
Proprietary Laboratory Analyses	0432U	Kelch-like protein 11 (KLHL11) antibody, serum or cerebrospinal fluid (CSF), cell-binding assay, qualitative
Proprietary Laboratory Analyses	0433U	Oncology (prostate), 5 DNA regulatory markers by quantitative PCR, whole blood, algorithm, including prostate-specific antigen, reported as likelihood of cancer
Proprietary Laboratory Analyses	0434U	Drug metabolism (adverse drug reactions and drug response), genomic analysis panel, variant analysis of 25 genes with reported phenotypes
Proprietary Laboratory Analyses	0435U	Oncology, chemotherapeutic drug cytotoxicity assay of cancer stem cells (CSCs), from cultured CSCs and primary tumor cells, categorical drug response reported based on cytotoxicity percentage observed, minimum of 14 drugs or drug combinations
Proprietary Laboratory Analyses	0436U	Oncology (lung), plasma analysis of 388 proteins, using aptamer-based proteomics technology, predictive algorithm reported as clinical benefit from immune checkpoint inhibitor therapy
Proprietary Laboratory Analyses	0437U	Psychiatry (anxiety disorders), mRNA, gene expression profiling by RNA sequencing of 15 biomarkers, whole blood, algorithm reported as predictive risk score
Proprietary Laboratory Analyses	0438U	Drug metabolism (adverse drug reactions and drug response), buccal specimen, gene-drug interactions, variant analysis of 33 genes, including deletion/duplication analysis of CYP2D6, including reported phenotypes and impacted gene- drug interactions

Category III

Category III	0784T	Insertion or replacement of percutaneous electrode array, spinal, with integrated neurostimulator, including imaging guidance, when performed
Category III	0785T	Revision or removal of neurostimulator electrode array, spinal, with integrated neurostimulator
Category III	0786T	Insertion or replacement of percutaneous electrode array, sacral, with integrated neurostimulator, including imaging guidance, when performed
Category III	0787T	Revision or removal of neurostimulator electrode array, sacral, with integrated neurostimulator
Category III	0788T	Electronic analysis with simple programming of implanted integrated neurostimulation system (eg, electrode array and receiver), including contact group(s), amplitude, pulse width, frequency (Hz), on/off cycling, burst, dose lockout, patient-selectable parameters, responsive neurostimulation, detection algorithms, closed-loop parameters, and passive parameters, when performed by physician or other qualified health care professional, spinal cord or sacral nerve, 1-3 parameters

Speciality	CPT Code	Description
Category III	0789T	Electronic analysis with complex programming of implanted integrated neurostimulation system (eg, electrode array and receiver), including contact group(s), amplitude, pulse width, frequency (Hz), on/off cycling, burst, dose lockout, patient-selectable parameters, responsive neurostimulation, detection algorithms, closed-loop parameters, and passive parameters, when performed by physician or other qualified health care professional, spinal cord or sacral nerve, 4 or more parameters
Category III	0790T	Revision (eg, augmentation, division of tether), replacement, or removal of thoracolumbar or lumbar vertebral body tethering, including thoracoscopy, when performed
Category III	0811T	Remote multi-day complex uroflowmetry (eg, calibrated electronic equipment); set-up and patient education on use of equipment
Category III	0812T	Remote multi-day complex uroflowmetry (eg, calibrated electronic equipment); device supply with automated report generation, up to 10 days
Category III	0813T	Esophagogastroduodenoscopy, flexible, transoral, with volume adjustment of intragastric bariatric balloon
Category III	0814T	Percutaneous injection of calcium-based biodegradable osteoconductive material, proximal femur, including imaging guidance, unilateral
Category III	0815T	Ultrasound-based radiofrequency echographic multi-spectrometry (REMS), bone-density study and fracture-risk assessment, 1 or more sites, hips, pelvis, or spine
Category III	0816T	Open insertion or replacement of integrated neurostimulation system for bladder dysfunction including electrode(s) (eg, array or leadless), and pulse generator or receiver, including analysis, programming, and imaging guidance, when performed, posterior tibial nerve; subcutaneous
Category III	0817T	Open insertion or replacement of integrated neurostimulation system for bladder dysfunction including electrode(s) (eg, array or leadless), and pulse generator or receiver, including analysis, programming, and imaging guidance, when performed, posterior tibial nerve; subfascial
Category III	0818T	Revision or removal of integrated neurostimulation system for bladder dysfunction, including analysis, programming, and imaging, when performed, posterior tibial nerve; subcutaneous
Category III	0819T	Revision or removal of integrated neurostimulation system for bladder dysfunction, including analysis, programming, and imaging, when performed, posterior tibial nerve; subfascial
Category III	0820T	Continuous in-person monitoring and intervention (eg, psychotherapy, crisis intervention), as needed, during psychedelic medication therapy; first physician or other qualified health care professional, each hour
Category III	0821T	Continuous in-person monitoring and intervention (eg, psychotherapy, crisis intervention), as needed, during psychedelic medication therapy; second physician or other qualified health care professional, concurrent with first physician or other qualified health care professional, each hour (List separately in addition to code for primary procedure)
Category III	0822T	Continuous in-person monitoring and intervention (eg, psychotherapy, crisis intervention), as needed, during psychedelic medication therapy; clinical staff under the direction of a physician or other qualified health care professional, concurrent with first physician or other qualified health care professional, each hour (List separately in addition to code for primary procedure)
Category III	0823T	Transcatheter insertion of permanent single-chamber leadless pacemaker, right atrial, including imaging guidance (eg, fluoroscopy, venous ultrasound, right atrial angiography and/or right ventriculography, femoral venography, cavography) and device evaluation (eg, interrogation or programming), when performed
Category III	0824T	Transcatheter removal of permanent single-chamber leadless pacemaker, right atrial, including imaging guidance (eg, fluoroscopy, venous ultrasound, right atrial angiography and/or right ventriculography, femoral venography, cavography), when performed
Category III	0825T	Transcatheter removal and replacement of permanent single-chamber leadless pacemaker, right atrial, including imaging guidance (eg, fluoroscopy, venous ultrasound, right atrial angiography and/or right ventriculography, femoral venography, cavography) and device evaluation (eg, interrogation or programming), when performed
Category III	0826T	Programming device evaluation (in person) with iterative adjustment of the implantable device to test the function of the device and select optimal permanent programmed values with analysis, review and report by a physician or other qualified health care professional, leadless pacemaker system in single-cardiac chamber
Category III	0827T	Digitization of glass microscope slides for cytopathology, fluids, washings, or brushings, except cervical or vaginal; smears with interpretation (List separately in addition to code for primary procedure)
Category III	0828T	Digitization of glass microscope slides for cytopathology, fluids, washings, or brushings, except cervical or vaginal; simple filter method with interpretation (List separately in addition to code for primary procedure)
Category III	0829T	Digitization of glass microscope slides for cytopathology, concentration technique, smears, and interpretation (eg, Saccomanno technique) (List separately in addition to code for primary procedure)
Category III	0830T	Digitization of glass microscope slides for cytopathology, selective-cellular enhancement technique with interpretation (eg, liquid-based slide preparation method), except cervical or vaginal (List separately in addition to code for primary procedure)
Category III	0831T	Digitization of glass microscope slides for cytopathology, cervical or vaginal (any reporting system), requiring interpretation by physician (List separately in addition to code for primary procedure)
Category III	0832T	Digitization of glass microscope slides for cytopathology, smears, any other source; screening and interpretation (List separately in addition to code for primary procedure)
Category III	0833T	Digitization of glass microscope slides for cytopathology, smears, any other source; preparation, screening and interpretation (List separately in addition to code for primary procedure)

Speciality	CPT Code	Description
Category III	0834T	Digitization of glass microscope slides for cytopathology, smears, any other source; extended study involving over 5 slides and/or multiple stains (List separately in addition to code for primary procedure)
Category III	0835T	Digitization of glass microscope slides for cytopathology, evaluation of fine needle aspirate; immediate cytohistologic study to determine adequacy for diagnosis, first evaluation episode, each site (List separately in addition to code for primary procedure)
Category III	0836T	Digitization of glass microscope slides for cytopathology, evaluation of fine needle aspirate; immediate cytohistologic study to determine adequacy for diagnosis, each separate additional evaluation episode, same site (List separately in addition to code for primary procedure)
Category III	0837T	Digitization of glass microscope slides for cytopathology, evaluation of fine needle aspirate; interpretation and report (List separately in addition to code for primary procedure)
Category III	0838T	Digitization of glass microscope slides for consultation and report on referred slides prepared elsewhere (List separately in addition to code for primary procedure)
Category III	0839T	Digitization of glass microscope slides for consultation and report on referred material requiring preparation of slides (List separately in addition to code for primary procedure)
Category III	0840T	Digitization of glass microscope slides for consultation, comprehensive, with review of records and specimens, with report on referred material (List separately in addition to code for primary procedure)
Category III	0841T	Digitization of glass microscope slides for pathology consultation during surgery; first tissue block, with frozen section(s), single specimen (List separately in addition to code for primary procedure)
Category III	0842T	Digitization of glass microscope slides for pathology consultation during surgery; each additional tissue block with frozen section(s) (List separately in addition to code for primary procedure)
Category III	0843T	Digitization of glass microscope slides for pathology consultation during surgery; cytologic examination (eg, touch preparation, squash preparation), initial site (List separately in addition to code for primary procedure)
Category III	0844T	Digitization of glass microscope slides for pathology consultation during surgery; cytologic examination (eg, touch preparation, squash preparation), each additional site (List separately in addition to code for primary procedure)
Category III	0845T	Digitization of glass microscope slides for immunofluorescence, per specimen; initial single antibody stain procedure (List separately in addition to code for primary procedure)
Category III	0846T	Digitization of glass microscope slides for immunofluorescence, per specimen; each additional single antibody stain procedure (List separately in addition to code for primary procedure)
Category III	0847T	Digitization of glass microscope slides for examination and selection of retrieved archival (ie, previously diagnosed) tissue(s) for molecular analysis (eg, KRAS mutational analysis) (List separately in addition to code for primary procedure)
Category III	0848T	Digitization of glass microscope slides for in situ hybridization (eg, FISH), per specimen; initial single probe stain procedure (List separately in addition to code for primary procedure)
Category III	0849T	Digitization of glass microscope slides for in situ hybridization (eg, FISH), per specimen; each additional single probe stain procedure (List separately in addition to code for primary procedure)
Category III	0850T	Digitization of glass microscope slides for in situ hybridization (eg, FISH), per specimen; each multiplex probe stain procedure (List separately in addition to code for primary procedure)
Category III	0851T	Digitization of glass microscope slides for morphometric analysis, in situ hybridization (quantitative or semiquantitative), manual, per specimen; initial single probe stain procedure (List separately in addition to code for primary procedure)
Category III	0852T	Digitization of glass microscope slides for morphometric analysis, in situ hybridization (quantitative or semiquantitative), manual, per specimen; each additional single probe stain procedure (List separately in addition to code for primary procedure)
Category III	0853T	Digitization of glass microscope slides for morphometric analysis, in situ hybridization (quantitative or semiquantitative), manual, per specimen; each multiplex probe stain procedure (List separately in addition to code for primary procedure)
Category III	0854T	Digitization of glass microscope slides for blood smear, peripheral, interpretation by physician with written report (List separately in addition to code for primary procedure)
Category III	0855T	Digitization of glass microscope slides for bone marrow, smear interpretation (List separately in addition to code for primary procedure)
Category III	0856T	Digitization of glass microscope slides for electron microscopy, diagnostic (List separately in addition to code for primary procedure)
Category III	0857T	Opto-acoustic imaging, breast, unilateral, including axilla when performed, real-time with image documentation, augmentative analysis and report (List separately in addition to code for primary procedure)
Category III	0858T	Externally applied transcranial magnetic stimulation with concomitant measurement of evoked cortical potentials with automated report
Category III	0859T	Noncontact near-infrared spectroscopy (eg, for measurement of deoxyhemoglobin, oxyhemoglobin, and ratio of tissue oxygenation), other than for screening for peripheral arterial disease, image acquisition, interpretation, and report; each additional anatomic site (List separately in addition to code for primary procedure)
Category III	0860T	Noncontact near-infrared spectroscopy (eg, for measurement of deoxyhemoglobin, oxyhemoglobin, and ratio of tissue oxygenation), for screening for peripheral arterial disease, including provocative maneuvers, image acquisition, interpretation, and report, one or both lower extremities
Category III	0861T	Removal of pulse generator for wireless cardiac stimulator for left ventricular pacing; both components (battery and transmitter)
Category III	0862T	Relocation of pulse generator for wireless cardiac stimulator for left ventricular pacing, including device interrogation and programming; battery component only

Speciality	CPT Code	Description
Category III	0863T	Relocation of pulse generator for wireless cardiac stimulator for left ventricular pacing, including device interrogation and programming; transmitter component only
Category III	0864T	Low-intensity extracorporeal shock wave therapy involving corpus cavernosum, low energy
Category III	0865T	Quantitative magnetic resonance image (MRI) analysis of the brain with comparison to prior magnetic resonance (MR) study(ies), including lesion identification, characterization, and quantification, with brain volume(s) quantification and/ or severity score, when performed, data preparation and transmission, interpretation and report, obtained without diagnostic MRI examination of the brain during the same session
Category III	0866T	Quantitative magnetic resonance image (MRI) analysis of the brain with comparison to prior magnetic resonance (MR) study(ies), including lesion detection, characterization, and quantification, with brain volume(s) quantification and/or severity score, when performed, data preparation and transmission, interpretation and report, obtained with diagnostic MRI examination of the brain (List separately in addition to code for primary procedure)

Surgery

Surgery	22836	Anterior thoracic vertebral body tethering, including thoracoscopy, when performed; up to 7 vertebral segments
Surgery	22837	Anterior thoracic vertebral body tethering, including thoracoscopy, when performed; 8 or more vertebral segments
Surgery	22838	Revision (eg, augmentation, division of tether), replacement, or removal of thoracic vertebral body tethering, including thoracoscopy, when performed
Surgery	27278	Arthrodesis, sacroiliac joint, percutaneous, with image guidance, including placement of intra-articular implant(s) (eg, bone allograft[s], synthetic device[s]), without placement of transfixation device
Surgery	31242	Nasal/sinus endoscopy, surgical; with destruction by radiofrequency ablation, posterior nasal nerve
Surgery	31243	Nasal/sinus endoscopy, surgical; with destruction by cryoablation, posterior nasal nerve
Surgery	33276	Insertion of phrenic nerve stimulator system (pulse generator and stimulating lead[s]), including vessel catheterization, all imaging guidance, and pulse generator initial analysis with diagnostic mode activation, when performed
Surgery	33277	Insertion of phrenic nerve stimulator transvenous sensing lead (List separately in addition to code for primary procedure)
Surgery	33278	Removal of phrenic nerve stimulator, including vessel catheterization, all imaging guidance, and interrogation and programming, when performed; system, including pulse generator and lead(s)
Surgery	33279	Removal of phrenic nerve stimulator, including vessel catheterization, all imaging guidance, and interrogation and programming, when performed; transvenous stimulation or sensing lead(s) only
Surgery	33280	Removal of phrenic nerve stimulator, including vessel catheterization, all imaging guidance, and interrogation and programming, when performed; pulse generator only
Surgery	33281	Repositioning of phrenic nerve stimulator transvenous lead(s)
Surgery	33287	Removal and replacement of phrenic nerve stimulator, including vessel catheterization, all imaging guidance, and interrogation and programming, when performed; pulse generator
Surgery	33288	Removal and replacement of phrenic nerve stimulator, including vessel catheterization, all imaging guidance, and interrogation and programming, when performed; transvenous stimulation or sensing lead(s)
Surgery	52284	Cystourethroscopy, with mechanical urethral dilation and urethral therapeutic drug delivery by drug-coated balloon catheter for urethral stricture or stenosis, male, including fluoroscopy, when performed
Surgery	58580	Transcervical ablation of uterine fibroid(s), including intraoperative ultrasound guidance and monitoring, radiofrequency
Surgery	61889	Insertion of skull-mounted cranial neurostimulator pulse generator or receiver, including craniectomy or craniotomy, when performed, with direct or inductive coupling, with connection to depth and/or cortical strip electrode array(s)
Surgery	61891	Revision or replacement of skull-mounted cranial neurostimulator pulse generator or receiver with connection to depth and/or cortical strip electrode array(s)
Surgery	61892	Removal of skull-mounted cranial neurostimulator pulse generator or receiver with cranioplasty, when performed
Surgery	64596	Insertion or replacement of percutaneous electrode array, peripheral nerve, with integrated neurostimulator, including imaging guidance, when performed; initial electrode array
Surgery	64597	Insertion or replacement of percutaneous electrode array, peripheral nerve, with integrated neurostimulator, including imaging guidance, when performed; each additional electrode array (List separately in addition to code for primary procedure)
Surgery	64598	Revision or removal of neurostimulator electrode array, peripheral nerve, with integrated neurostimulator
Surgery	67516	Suprachoroidal space injection of pharmacologic agent (separate procedure)

Radiology

Radiology	75580	Noninvasive estimate of coronary fractional flow reserve (FFR) derived from augmentative software analysis of the data set from a coronary computed tomography angiography, with interpretation and report by a physician or other qualified health care professional
Radiology	76984	Ultrasound, intraoperative thoracic aorta (eg, epiaortic), diagnostic
Radiology	76987	Intraoperative epicardial cardiac ultrasound (ie, echocardiography) for congenital heart disease, diagnostic; including placement and manipulation of transducer, image acquisition, interpretation and report
Radiology	76988	Intraoperative epicardial cardiac ultrasound (ie, echocardiography) for congenital heart disease, diagnostic; placement, manipulation of transducer, and image acquisition only

Speciality	CPT Code	Description
Radiology	76989	Intraoperative epicardial cardiac ultrasound (ie, echocardiography) for congenital heart disease, diagnostic; interpretation and report only

Pathology and Laboratory

Pathology and Laboratory	81457	Solid organ neoplasm, genomic sequence analysis panel, interrogation for sequence variants; DNA analysis, microsatellite instability
Pathology and Laboratory	81458	Solid organ neoplasm, genomic sequence analysis panel, interrogation for sequence variants; DNA analysis, copy number variants and microsatellite instability
Pathology and Laboratory	81459	Solid organ neoplasm, genomic sequence analysis panel, interrogation for sequence variants; DNA analysis or combined DNA and RNA analysis, copy number variants, microsatellite instability, tumor mutation burden, and rearrangements
Pathology and Laboratory	81462	Solid organ neoplasm, genomic sequence analysis panel, cell-free nucleic acid (eg, plasma), interrogation for sequence variants; DNA analysis or combined DNA and RNA analysis, copy number variants and rearrangements
Pathology and Laboratory	81463	Solid organ neoplasm, genomic sequence analysis panel, cell-free nucleic acid (eg, plasma), interrogation for sequence variants; DNA analysis, copy number variants, and microsatellite instability
Pathology and Laboratory	81464	Solid organ neoplasm, genomic sequence analysis panel, cell-free nucleic acid (eg, plasma), interrogation for sequence variants; DNA analysis or combined DNA and RNA analysis, copy number variants, microsatellite instability, tumor mutation burden, and rearrangements
Pathology and Laboratory	81517	Liver disease, analysis of 3 biomarkers (hyaluronic acid [HA], procollagen III amino terminal peptide [PIIINP], tissue inhibitor of metalloproteinase 1 [TIMP-1]), using immunoassays, utilizing serum, prognostic algorithm reported as a risk score and risk of liver fibrosis and liver-related clinical events within 5 years
Pathology and Laboratory	82166	Anti-mullerian hormone (AMH)
Pathology and Laboratory	86041	Acetylcholine receptor (AChR); binding antibody
Pathology and Laboratory	86042	Acetylcholine receptor (AChR); blocking antibody
Pathology and Laboratory	86043	Acetylcholine receptor (AChR); modulating antibody
Pathology and Laboratory	86366	Muscle-specific kinase (MuSK) antibody
Pathology and Laboratory	87523	Infectious agent detection by nucleic acid (DNA or RNA); hepatitis D (delta), quantification, including reverse transcription, when performed

Medicine Services and Procedures

Medicine Services and Procedures	90589	Chikungunya virus vaccine, live attenuated, for intramuscular use
Medicine Services and Procedures	90623	Meningococcal pentavalent vaccine, conjugated Men A, C, W, Y- tetanus toxoid carrier, and Men B-FHbp, for intramuscular usew
Medicine Services and Procedures	90683	Respiratory syncytial virus vaccine, mRNA lipid nanoparticles, for intramuscular use
Medicine Services and Procedures	92622	Diagnostic analysis, programming, and verification of an auditory osseointegrated sound processor, any type; first 60 minutes
Medicine Services and Procedures	92623	Diagnostic analysis, programming, and verification of an auditory osseointegrated sound processor, any type; each additional 15 minutes (List separately in addition to code for primary procedure)
Medicine Services and Procedures	92972	Percutaneous transluminal coronary lithotripsy (List separately in addition to code for primary procedure)
Medicine Services and Procedures	93150	Therapy activation of implanted phrenic nerve stimulator system, including all interrogation and programming
Medicine Services and Procedures	93151	Interrogation and programming (minimum one parameter) of implanted phrenic nerve stimulator system
Medicine Services and Procedures	93152	Interrogation and programming of implanted phrenic nerve stimulator system during polysomnography
Medicine Services and Procedures	93153	Interrogation without programming of implanted phrenic nerve stimulator system
Medicine Services and Procedures	93584	Venography for congenital heart defect(s), including catheter placement, and radiological supervision and interpretation; anomalous or persistent superior vena cava when it exists as a second contralateral superior vena cava, with native drainage to heart (List separately in addition to code for primary procedure)
Medicine Services and Procedures	93585	Venography for congenital heart defect(s), including catheter placement, and radiological supervision and interpretation; azygos/hemiazygos venous system (List separately in addition to code for primary procedure)
Medicine Services and Procedures	93586	Venography for congenital heart defect(s), including catheter placement, and radiological supervision and interpretation; coronary sinus (List separately in addition to code for primary procedure)
Medicine Services and Procedures	93587	Venography for congenital heart defect(s), including catheter placement, and radiological supervision and interpretation; venovenous collaterals originating at or above the heart (eg, from innominate vein) (List separately in addition to code for primary procedure)
Medicine Services and Procedures	93588	Venography for congenital heart defect(s), including catheter placement, and radiological supervision and interpretation; venovenous collaterals originating below the heart (eg, from the inferior vena cava) (List separately in addition to code for primary procedure)
Medicine Services and Procedures	96547	Intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) procedure, including separate incision(s) and closure, when performed; first 60 minutes (List separately in addition to code for primary procedure)
Medicine Services and Procedures	96548	Intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) procedure, including separate incision(s) and closure, when performed; each additional 30 minutes (List separately in addition to code for primary procedure)

Speciality	CPT Code	Description
Medicine Services and Procedures	97037	Application of a modality to 1 or more areas; low-level laser therapy (ie, nonthermal and non-ablative) for post-operative pain reduction
Medicine Services and Procedures	97550	Caregiver training in strategies and techniques to facilitate the patient’s functional performance in the home or community (eg, activities of daily living [ADLs], instrumental ADLs [iADLs], transfers, mobility, communication, swallowing, feeding, problem solving, safety practices) (without the patient present), face to face; initial 30 minutes
Medicine Services and Procedures	97551	Caregiver training in strategies and techniques to facilitate the patient’s functional performance in the home or community (eg, activities of daily living [ADLs], instrumental ADLs [iADLs], transfers, mobility, communication, swallowing, feeding, problem solving, safety practices) (without the patient present), face to face; each additional 15 minutes (List separately in addition to code for primary service)
Medicine Services and Procedures	97552	Group caregiver training in strategies and techniques to facilitate the patient's functional performance in the home or community (eg, activities of daily living [ADLs], instrumental ADLs [iADLs], transfers, mobility, communication, swallowing, feeding, problem solving, safety practices) (without the patient present), face to face with multiple sets of caregivers

Evaluation and Management

99459

Pelvic examination (List separately in addition to code for primary procedure)

Speciality

CPT

Code

2024 Description

2023 Description

Proprietary Laboratory Analyses

0351U

Infectious disease (bacterial or viral), biochemical assays, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein, serum, or venous whole blood, algorithm reported as likelihood of bacterial infection

Infectious disease (bacterial or viral), biochemical assays,

tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and

C-reactive protein, serum, algorithm reported as likelihood of bacterial infection

Proprietary Laboratory Analyses

0356U

Oncology (oropharyngeal or anal), evaluation of 17 DNA biomarkers using droplet digital PCR (ddPCR), cell-free DNA, algorithm reported as a prognostic risk score for cancer recurrence

Oncology (oropharyngeal), evaluation of 17 DNA biomarkers using droplet digital PCR (ddPCR), cell-free DNA, algorithm reported as a prognostic risk score for cancer recurrence

Category III

Category III	0517T	Insertion of wireless cardiac stimulator for left ventricular pacing, including device interrogation and programming, and imaging supervision and interpretation, when performed; both components of pulse generator (battery and transmitter) only	Insertion of wireless cardiac stimulator for left ventricular pacing, including device interrogation and programming, and imaging supervision and interpretation, when performed; pulse generator component(s) (battery and/or transmitter) only
Category III	0518T	Removal of pulse generator for wireless cardiac stimulator for left ventricular pacing; battery component only	Removal of only pulse generator component(s) (battery and/ or transmitter) of wireless cardiac stimulator for left ventricular pacing
Category III	0519T	Removal and replacement of pulse generator for wireless cardiac stimulator for left ventricular pacing, including device interrogation and programming; both components (battery and transmitter)	Removal and replacement of wireless cardiac stimulator for left ventricular pacing; pulse generator component(s) (battery and/ or transmitter)
Category III	0520T	Removal and replacement of pulse generator for wireless cardiac stimulator for left ventricular pacing, including device interrogation and programming; battery component only	Removal and replacement of wireless cardiac stimulator for left ventricular pacing; pulse generator component(s) (battery and/or transmitter), including placement of a new electrode
Category III	0587T	Percutaneous implantation or replacement of integrated single device neurostimulation system for bladder dysfunction including electrode array and receiver or pulse generator, including analysis, programming, and imaging guidance when performed, posterior tibial nerve	Percutaneous implantation or replacement of integrated single device neurostimulation system including electrode array and receiver or pulse generator, including analysis, programming, and imaging guidance when performed, posterior tibial nerve
Category III	0588T	Revision or removal of percutaneously placed integrated single device neurostimulation system for bladder dysfunction including electrode array and receiver or pulse generator, including analysis, programming, and imaging guidance when performed, posterior tibial nerve	Revision or removal of integrated single device neurostimulation system including electrode array and receiver or pulse generator, including analysis, programming, and imaging guidance when performed, posterior tibial nerve
Category III	0589T	Electronic analysis with simple programming of implanted integrated neurostimulation system for bladder dysfunction (eg, electrode array and receiver), including contact group(s), amplitude, pulse width, frequency (Hz), on/off cycling, burst, dose lockout, patient-selectable parameters, responsive neurostimulation, detection algorithms, closed-loop parameters, and passive parameters, when performed by physician or other qualified health care professional, posterior tibial nerve, 1-3 parameters	Electronic analysis with simple programming of implanted integrated neurostimulation system (eg, electrode array and receiver), including contact group(s), amplitude, pulse width, frequency (Hz), on/off cycling, burst, dose lockout, patient- selectable parameters, responsive neurostimulation, detection algorithms, closed-loop parameters, and passive parameters, when performed by physician or other qualified health care professional, posterior tibial nerve, 1-3 parameters
Category III	0590T	Electronic analysis with complex programming of implanted integrated neurostimulation system for bladder dysfunction (eg, electrode array and receiver), including contact group(s), amplitude, pulse width, frequency (Hz), on/off cycling, burst, dose lockout, patient-selectable parameters, responsive neurostimulation, detection algorithms, closed-loop parameters, and passive parameters, when performed by physician or other qualified health care professional, posterior tibial nerve, 4 or more parameters	Electronic analysis with complex programming of implanted integrated neurostimulation system (eg, electrode array and receiver), including contact group(s), amplitude, pulse width, frequency (Hz), on/off cycling, burst, dose lockout, patient- selectable parameters, responsive neurostimulation, detection algorithms, closed-loop parameters, and passive parameters, when performed by physician or other qualified health care professional, posterior tibial nerve, 4 or more parameters
Category III	0640T	Noncontact near-infrared spectroscopy (eg, for measurement of deoxyhemoglobin, oxyhemoglobin, and ratio of tissue oxygenation), other than for screening for peripheral arterial disease, image acquisition, interpretation, and report; first anatomic site	Noncontact near-infrared spectroscopy studies of flap or wound (eg, for measurement of deoxyhemoglobin, oxyhemoglobin, and ratio of tissue oxygenation [StO2]); image acquisition, interpretation and report, each flap or wound
Category III	0656T	Anterior lumbar or thoracolumbar vertebral body tethering; up to 7 vertebral segments	Vertebral body tethering, anterior; up to 7 vertebral segments
Category III	0657T	Anterior lumbar or thoracolumbar vertebral body tethering; 8 or more vertebral segments	Vertebral body tethering, anterior; 8 or more vertebral segments
Category III	0766T	Transcutaneous magnetic stimulation by focused low-frequency electromagnetic pulse, peripheral nerve, with identification and marking of the treatment location, including noninvasive electroneurographic localization (nerve conduction localization), when performed; first nerve	Transcutaneous magnetic stimulation by focused low-frequency electromagnetic pulse, peripheral nerve, initial treatment, with identification and marking of the treatment location, including noninvasive electroneurographic localization (nerve conduction localization), when performed; first nerve

Speciality

CPT

Code

2024 Description

2023 Description

Category III

0767T

Transcutaneous magnetic stimulation by focused

low-frequency electromagnetic pulse, peripheral nerve, with identification and marking of the treatment location,

including noninvasive electroneurographic localization (nerve conduction localization), when performed; each additional nerve (List separately in addition to code for

primary procedure)

Transcutaneous magnetic stimulation by focused low-frequency electromagnetic pulse, peripheral nerve, initial treatment, with identification and marking of the treatment location, including noninvasive electroneurographic localization (nerve conduction localization), when performed; each additional nerve (List separately in addition to code for primary procedure)

Category II

Category II	1119F	Initial evaluation for condition (HEP C) (EPI, DSP)	Initial evaluation for condition (HEP C)(EPI, DSP)
Category II	1121F	Subsequent evaluation for condition (HEP C) (EPI)	Subsequent evaluation for condition (HEP C)(EPI)

Surgery

Radiology

Radiology	77402	Radiation treatment delivery, >=1 MeV; simple	Radiation treatment delivery, >/=1 MeV; simple
Radiology	77407	Radiation treatment delivery, >=1 MeV; intermediate	Radiation treatment delivery, >/=1 MeV; intermediate
Radiology	77412	Radiation treatment delivery, >=1 MeV; complex	Radiation treatment delivery, >/=1 MeV; complex

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory

81171

AFF2 (ALF transcription elongation factor 2 [FMR2]) (eg, fragile X intellectual disability 2 [FRAXE]) gene analysis; evaluation to detect abnormal (eg, expanded) alleles

AFF2 (AF4/FMR2 family, member 2 [FMR2]) (eg, fragile X mental retardation 2 [FRAXE]) gene analysis; evaluation to detect abnormal (eg, expanded) alleles+A32:C47+C36

Pathology and Laboratory

81172

AFF2 (ALF transcription elongation factor 2 [FMR2]) (eg, fragile X intellectual disability 2 [FRAXE]) gene analysis; characterization of alleles (eg, expanded size and methylation status)

AFF2 (AF4/FMR2 family, member 2 [FMR2]) (eg, fragile X mental retardation 2 [FRAXE]) gene analysis; characterization of alleles (eg, expanded size and methylation status)

Pathology and Laboratory

81243

FMR1 (fragile X messenger ribonucleoprotein 1) (eg, fragile X syndrome, X-linked intellectual disability [XLID]) gene analysis; evaluation to detect abnormal (eg, expanded) alleles

FMR1 (fragile X mental retardation 1) (eg, fragile X mental retardation) gene analysis; evaluation to detect abnormal (eg, expanded) alleles

Pathology and Laboratory

81244

FMR1 (fragile X messenger ribonucleoprotein 1) (eg, fragile X syndrome, X-linked intellectual disability [XLID]) gene analysis; characterization of alleles (eg, expanded size and promoter methylation status)

FMR1 (fragile X mental retardation 1) (eg, fragile X mental retardation) gene analysis; characterization of alleles (eg, expanded size and promoter methylation status)

Pathology and Laboratory

81403

Molecular pathology procedure, Level 4 (eg, analysis of single exon by DNA sequence analysis, analysis of >10 amplicons using multiplex PCR in 2 or more independent reactions, mutation scanning or duplication/deletion variants of 2-5 exons) ANG (angiogenin, ribonuclease, RNase A family, 5) (eg, amyotrophic lateral sclerosis), full gene sequence ARX (aristaless related homeobox) (eg, X-linked lissencephaly with ambiguous genitalia, X-linked intellectual disability), duplication/deletion analysis CEL (carboxyl ester lipase [bile salt-stimulated lipase]) (eg, maturity- onset diabetes of the young [MODY]), targeted sequence analysis of exon 11 (eg, c.1785delC, c.1686delT) CTNNB1 (catenin [cadherin-associated protein], beta 1, 88kDa) (eg, desmoid tumors), targeted sequence analysis (eg, exon 3) DAZ/SRY (deleted in azoospermia and sex determining region Y) (eg,

male infertility), common deletions (eg, AZFa, AZFb, AZFc, AZFd) DNMT3A (DNA [cytosine-5-]-methyltransferase 3 alpha) (eg, acute myeloid leukemia), targeted sequence analysis (eg, exon 23) EPCAM (epithelial cell adhesion molecule) (eg, Lynch syndrome), duplication/deletion analysis F8 (coagulation factor

VIII) (eg, hemophilia A), inversion analysis, intron 1 and intron 22A F12 (coagulation factor XII [Hageman factor]) (eg, angioedema, hereditary, type III; factor XII deficiency), targeted sequence analysis of exon 9 FGFR3 (fibroblast growth factor receptor 3) (eg, isolated craniosynostosis), targeted sequence analysis (eg, exon 7) (For targeted sequence analysis of multiple FGFR3 exons, use 81404) GJB1 (gap junction protein, beta 1) (eg, Charcot-Marie-Tooth X-linked), full gene sequence GNAQ (guanine nucleotide-binding protein G[q] subunit alpha) (eg, uveal melanoma), common variants (eg, R183, Q209) Human erythrocyte antigen gene analyses (eg, SLC14A1 [Kidd blood group], BCAM [Lutheran blood group], ICAM4 [Landsteiner-Wiener blood group], SLC4A1 [Diego blood group], AQP1 [Colton blood group], ERMAP [Scianna blood group], RHCE [Rh blood group, CcEe antigens], KEL [Kell blood group], DARC [Duffy blood group], GYPA, GYPB, GYPE [MNS blood group], ART4 [Dombrock blood group]) (eg, sickle-cell disease, thalassemia, hemolytic transfusion reactions, hemolytic disease of the fetus or newborn), common variants HRAS (v-Ha- ras Harvey rat sarcoma viral oncogene homolog) (eg, Costello syndrome), exon 2 sequence KCNC3 (potassium voltage-gated channel, Shaw-related subfamily, member 3) (eg, spinocerebellar ataxia), targeted sequence analysis (eg, exon 2) KCNJ2 (potassium inwardly-rectifying channel, subfamily J, member

2) (eg, Andersen-Tawil syndrome), full gene sequence KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11) (eg, familial hyperinsulinism), full gene sequence Killer cell

immunoglobulin-like receptor (KIR) gene family (eg, hematopoietic stem cell transplantation), genotyping of KIR family genes Known familial variant not otherwise specified, for gene listed in Tier 1

or Tier 2, or identified during a genomic sequencing procedure, DNA sequence analysis, each variant exon (For a known familial variant that is considered a common variant, use specific common variant Tier 1 or Tier 2 code) MC4R (melanocortin 4 receptor) (eg, obesity), full gene sequence MICA (MHC class I polypeptide- related sequence A) (eg, solid organ transplantation), common variants (eg, *001, *002) MT-RNR1 (mitochondrially encoded 12S RNA) (eg, nonsyndromic hearing loss), full gene sequence MT- TS1 (mitochondrially encoded tRNA serine 1) (eg, nonsyndromic hearing loss), full gene sequence NDP (Norrie disease [pseudoglioma]) (eg, Norrie disease), duplication/deletion analysis NHLRC1 (NHL repeat containing 1) (eg, progressive myoclonus epilepsy), full gene sequence PHOX2B (paired-like homeobox 2b)

genitalia, X-linked mental retardation), duplication/deletion analysisCEL (carboxyl ester lipase [bile salt-stimulated lipase]) (eg, maturity-onset diabetes of the young [MODY]), targeted sequence analysis of exon 11 (eg, c.1785delC, c.1686delT) CTNNB1 (catenin [cadherin-associated protein], beta 1, 88kDa) (eg, desmoid tumors), targeted sequence analysis (eg, exon 3) DAZ/SRY (deleted in azoospermia and sex determining region Y) (eg, male infertility), common deletions (eg, AZFa, AZFb, AZFc, AZFd)DNMT3A (DNA [cytosine-5-]-methyltransferase 3 alpha) (eg, acute myeloid leukemia), targeted sequence analysis (eg, exon 23)EPCAM (epithelial cell adhesion molecule) (eg, Lynch syndrome), duplication/deletion analysisF8 (coagulation factor VIII) (eg, hemophilia A), inversion analysis, intron 1 and intron 22AF12 (coagulation factor XII [Hageman factor]) (eg, angioedema, hereditary, type III; factor XII deficiency), targeted sequence analysis of exon 9FGFR3 (fibroblast growth factor receptor 3) (eg, isolated craniosynostosis), targeted sequence analysis (eg, exon 7)(For targeted sequence analysis of multiple FGFR3 exons, use 81404)GJB1 (gap junction protein, beta 1)

(eg, Charcot-Marie-Tooth X-linked), full gene sequenceGNAQ (guanine nucleotide-binding protein G[q] subunit alpha) (eg, uveal melanoma), common variants (eg, R183, Q209)Human erythrocyte antigen gene analyses (eg, SLC14A1 [Kidd blood group], BCAM [Lutheran blood group], ICAM4 [Landsteiner-Wiener blood

group], SLC4A1 [Diego blood group], AQP1 [Colton blood group], ERMAP [Scianna blood group], RHCE [Rh blood group, CcEe antigens], KEL [Kell blood group], DARC [Duffy blood group], GYPA, GYPB, GYPE [MNS blood group], ART4 [Dombrock blood group]) (eg, sickle-cell disease, thalassemia, hemolytic transfusion reactions, hemolytic disease of the fetus or newborn), common variantsHRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog) (eg, Costello syndrome), exon 2 sequenceKCNC3 (potassium voltage-gated channel, Shaw-related subfamily, member 3) (eg, spinocerebellar ataxia), targeted sequence analysis (eg, exon 2)KCNJ2 (potassium inwardly-rectifying channel, subfamily J, member 2) (eg, Andersen-Tawil syndrome), full gene sequenceKCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11) (eg, familial hyperinsulinism), full gene sequenceKiller cell immunoglobulin-like receptor (KIR) gene family (eg, hematopoietic stem cell transplantation), genotyping of KIR family genesKnown familial variant not otherwise specified, for gene listed in Tier 1 or Tier 2, or identified during a genomic sequencing procedure, DNA sequence analysis, each variant exon(For a known familial variant that is considered a common variant, use specific common variant Tier 1 or Tier 2 code)MC4R (melanocortin 4 receptor) (eg, obesity), full gene sequenceMICA (MHC class I polypeptide-related sequence A) (eg, solid organ transplantation), common variants (eg, *001, *002)MT-RNR1 (mitochondrially encoded 12S RNA) (eg, nonsyndromic hearing loss), full gene sequenceMT-TS1 (mitochondrially encoded tRNA serine 1) (eg, nonsyndromic hearing loss), full gene sequenceNDP (Norrie disease [pseudoglioma]) (eg, congenital central hypoventilation syndrome), duplication/deletion analysisPLN (phospholamban) (eg, dilated cardiomyopathy,

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory (continued)

81403

(eg, congenital central hypoventilation syndrome), duplication/ deletion analysis PLN (phospholamban) (eg, dilated cardiomyopathy, hypertrophic cardiomyopathy), full gene sequence RHD (Rh blood group, D antigen) (eg, hemolytic disease of the fetus and newborn, Rh maternal/fetal compatibility), deletion analysis (eg, exons 4, 5, and 7, pseudogene) RHD (Rh blood group, D antigen) (eg, hemolytic disease of the fetus and newborn, Rh maternal/fetal compatibility), deletion analysis (eg, exons 4, 5, and 7, pseudogene), performed on cell-free fetal DNA in maternal blood (For human erythrocyte gene analysis of RHD, use a separate unit of 81403) SH2D1A (SH2 domain containing

1A) (eg, X-linked lymphoproliferative syndrome), duplication/ deletion analysis TWIST1 (twist homolog 1 [Drosophila]) (eg, Saethre-Chotzen syndrome), duplication/deletion analysis UBA1 (ubiquitin-like modifier activating enzyme 1) (eg, spinal muscular atrophy, X-linked), targeted sequence analysis (eg, exon 15) VHL (von Hippel-Lindau tumor suppressor) (eg, von Hippel-Lindau familial cancer syndrome), deletion/duplication analysis VWF (von Willebrand factor) (eg, von Willebrand disease types 2A, 2B, 2M), targeted sequence analysis (eg, exon 28)

hypertrophic cardiomyopathy), full gene sequenceRHD (Rh blood group, D antigen) (eg, hemolytic disease of the fetus and newborn, Rh maternal/fetal compatibility), deletion analysis (eg, exons 4, 5, and 7, pseudogene)RHD (Rh blood group, D antigen) (eg, hemolytic disease of the fetus and newborn, Rh maternal/fetal compatibility), deletion analysis (eg, exons 4,

5, and 7, pseudogene), performed on cell-free fetal DNA in maternal blood(For human erythrocyte gene analysis of RHD, use a separate unit of 81403)SH2D1A (SH2 domain containing 1A) (eg, X-linked lymphoproliferative syndrome), duplication/ deletion analysisTWIST1 (twist homolog 1 [Drosophila]) (eg, Saethre-Chotzen syndrome), duplication/deletion analysisUBA1 (ubiquitin-like modifier activating enzyme 1) (eg, spinal muscular atrophy, X-linked), targeted sequence analysis (eg, exon 15)VHL (von Hippel-Lindau tumor suppressor) (eg, von Hippel-Lindau familial cancer syndrome), deletion/duplication analysisVWF (von Willebrand factor) (eg, von Willebrand disease types 2A, 2B, 2M), targeted sequence analysis (eg, exon 28)

Pathology and Laboratory

81404

Molecular pathology procedure, Level 5 (eg, analysis of 2-5 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 6-10 exons, or characterization of a dynamic mutation disorder/triplet repeat by Southern blot analysis) ACADS (acyl-CoA dehydrogenase, C-2 to C-3 short chain) (eg, short chain acyl-CoA dehydrogenase deficiency), targeted sequence analysis (eg, exons 5 and 6) AQP2 (aquaporin 2 [collecting duct]) (eg, nephrogenic diabetes insipidus), full gene sequence ARX (aristaless related homeobox) (eg, X-linked lissencephaly with ambiguous genitalia, X-linked intellectual disability), full gene sequence AVPR2 (arginine vasopressin receptor 2) (eg, nephrogenic diabetes insipidus), full gene sequence BBS10 (Bardet-Biedl syndrome 10) (eg, Bardet-Biedl syndrome), full gene sequence BTD (biotinidase) (eg, biotinidase deficiency), full gene sequence C10orf2 (chromosome 10 open reading frame 2) (eg, mitochondrial DNA depletion syndrome), full gene sequence CAV3 (caveolin 3) (eg, CAV3-related distal myopathy, limb-girdle muscular dystrophy type 1C), full gene sequence CD40LG (CD40 ligand) (eg,

CRX (cone-rod homeobox) (eg, cone-rod dystrophy 2, Leber congenital amaurosis), full gene sequence CYP1B1 (cytochrome P450, family

1, subfamily B, polypeptide 1) (eg, primary congenital glaucoma), full gene sequence EGR2 (early growth response 2) (eg, Charcot-

Marie-Tooth), full gene sequence EMD (emerin) (eg, Emery-Dreifuss muscular dystrophy), duplication/deletion analysis EPM2A (epilepsy, progressive myoclonus type 2A, Lafora disease [laforin]) (eg, progressive myoclonus epilepsy), full gene sequence FGF23 (fibroblast growth factor 23) (eg, hypophosphatemic rickets), full gene sequence FGFR2 (fibroblast growth factor receptor 2) (eg, craniosynostosis,

Apert syndrome, Crouzon syndrome), targeted sequence analysis (eg, exons 8, 10) FGFR3 (fibroblast growth factor receptor 3) (eg, achondroplasia, hypochondroplasia), targeted sequence analysis (eg, exons 8, 11, 12, 13) FHL1 (four and a half LIM domains 1) (eg, Emery-

Dreifuss muscular dystrophy), full gene sequence FKRP (fukutin related protein) (eg, congenital muscular dystrophy type 1C [MDC1C], limb- girdle muscular dystrophy [LGMD] type 2I), full gene sequence FOXG1 (forkhead box G1) (eg, Rett syndrome), full gene sequence FSHMD1A (facioscapulohumeral muscular dystrophy 1A) (eg, facioscapulohumeral muscular dystrophy), evaluation to detect abnormal (eg, deleted) alleles FSHMD1A (facioscapulohumeral muscular dystrophy 1A)

(eg, facioscapulohumeral muscular dystrophy), characterization of haplotype(s) (ie, chromosome 4A and 4B haplotypes) GH1 (growth hormone 1) (eg, growth hormone deficiency), full gene sequence GP1BB (glycoprotein Ib [platelet], beta polypeptide) (eg, Bernard- Soulier syndrome type B), full gene sequence (For common deletion variants of alpha globin 1 and alpha globin 2 genes, use 81257) HNF1B (HNF1 homeobox B) (eg, maturity-onset diabetes of the young [MODY]),duplication/deletion analysis HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog) (eg, Costello syndrome), full gene sequence HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2) (eg, 3-beta-hydroxysteroid dehydrogenase type II deficiency), full gene sequence HSD11B2 (hydroxysteroid [11-beta] dehydrogenase 2) (eg, mineralocorticoid excess syndrome), full gene sequence HSPB1 (heat shock 27kDa protein 1) (eg, Charcot-Marie-Tooth disease), full gene sequence INS (insulin) (eg, diabetes mellitus), full gene sequence KCNJ1

Molecular pathology procedure, Level 5 (eg, analysis of 2-5 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 6-10 exons, or characterization of a dynamic mutation disorder/triplet repeat by Southern blot analysis)ACADS (acyl-CoA dehydrogenase, C-2 to C-3 short chain) (eg, short chain acyl-CoA dehydrogenase deficiency), targeted sequence analysis (eg, exons 5 and 6)AQP2 (aquaporin 2 [collecting duct]) (eg, nephrogenic diabetes insipidus), full gene sequenceARX (aristaless related homeobox) (eg, X-linked lissencephaly with ambiguous genitalia, X-linked mental retardation), full gene sequenceAVPR2 (arginine vasopressin receptor 2) (eg, nephrogenic diabetes insipidus), full gene sequenceBBS10 (Bardet-Biedl syndrome 10) (eg, Bardet-Biedl syndrome), full gene sequenceBTD (biotinidase) (eg, biotinidase deficiency), full gene sequenceC10orf2 (chromosome 10 open reading frame 2) (eg, mitochondrial DNA depletion syndrome), full gene sequenceCAV3 (caveolin 3) (eg, CAV3-related distal myopathy, limb-girdle muscular dystrophy type 1C), full gene sequenceCD40LG (CD40 ligand) (eg,

X-linked hyper IgM syndrome), full gene sequenceCDKN2A (cyclin- dependent kinase inhibitor 2A) (eg, CDKN2A-related cutaneous malignant melanoma, familial atypical mole-malignant melanoma syndrome), full gene sequenceCLRN1 (clarin 1) (eg, Usher syndrome, type 3), full gene sequenceCOX6B1 (cytochrome c oxidase subunit VIb polypeptide 1) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequenceCPT2 (carnitine palmitoyltransferase 2) (eg, carnitine palmitoyltransferase II deficiency), full gene sequenceCRX (cone-rod homeobox) (eg, cone-rod dystrophy 2, Leber congenital amaurosis), full gene sequenceCYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1) (eg, primary congenital glaucoma), full gene sequenceEGR2 (early growth response 2) (eg, Charcot-Marie-Tooth), full gene sequenceEMD (emerin) (eg, Emery- Dreifuss muscular dystrophy), duplication/deletion analysisEPM2A (epilepsy, progressive myoclonus type 2A, Lafora disease [laforin]) (eg, progressive myoclonus epilepsy), full gene sequenceFGF23 (fibroblast growth factor 23) (eg, hypophosphatemic rickets), full gene sequenceFGFR2 (fibroblast growth factor receptor 2) (eg, craniosynostosis, Apert syndrome, Crouzon syndrome), targeted sequence analysis (eg, exons 8, 10)FGFR3 (fibroblast growth factor receptor 3) (eg, achondroplasia, hypochondroplasia), targeted sequence analysis (eg, exons 8, 11, 12, 13)FHL1 (four and a half LIM domains 1) (eg, Emery-Dreifuss muscular dystrophy), full gene sequenceFKRP (fukutin related protein) (eg, congenital muscular dystrophy type 1C [MDC1C], limb-girdle muscular dystrophy [LGMD] type 2I), full gene sequenceFOXG1 (forkhead box G1) (eg, Rett syndrome), full gene sequenceFSHMD1A (facioscapulohumeral

muscular dystrophy 1A) (eg, facioscapulohumeral muscular dystrophy), evaluation to detect abnormal (eg, deleted) allelesFSHMD1A (facioscapulohumeral muscular dystrophy 1A) (eg, facioscapulohumeral muscular dystrophy), characterization of haplotype(s) (ie, chromosome 4A and 4B haplotypes)GH1 (growth hormone 1) (eg, growth hormone deficiency), full gene sequenceGP1BB (glycoprotein Ib [platelet],

beta polypeptide) (eg, Bernard-Soulier syndrome type B), full gene sequence(For common deletion variants of alpha globin 1 and alpha globin 2 genes, use 81257)HNF1B (HNF1 homeobox B) (eg, maturity-onset diabetes of the young [MODY]), duplication/deletion

analysisHRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog) (eg, Costello syndrome), full gene sequenceHSD3B2 (hydroxy-delta- 5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2) (eg, 3-beta-hydroxysteroid dehydrogenase type II deficiency), full gene sequenceHSD11B2 (hydroxysteroid [11-beta] dehydrogenase 2) (eg, mineralocorticoid excess syndrome), full gene sequenceHSPB1 (heat shock 27kDa protein 1) (eg, Charcot-Marie-Tooth disease), full gene

sequenceINS (insulin) (eg, diabetes mellitus), full gene sequenceKCNJ1

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory (continued)

81404

(potassium inwardly-rectifying channel, subfamily J, member 1) (eg, Bartter syndrome), full gene sequence KCNJ10 (potassium inwardly- rectifying channel, subfamily J, member 10) (eg, SeSAME syndrome, EAST syndrome, sensorineural hearing loss), full gene sequence LITAF (lipopolysaccharide-induced TNF factor) (eg, Charcot-Marie-Tooth), full gene sequence MEFV (Mediterranean fever) (eg, familial Mediterranean fever), full gene sequence MEN1 (multiple endocrine neoplasia I) (eg, multiple endocrine neoplasia type 1, Wermer syndrome), duplication/ deletion analysis MMACHC (methylmalonic aciduria [cobalamin deficiency] cblC type, with homocystinuria) (eg, methylmalonic acidemia and homocystinuria), full gene sequence MPV17 (MpV17 mitochondrial inner membrane protein) (eg, mitochondrial DNA depletion syndrome), duplication/deletion analysis NDP (Norrie disease [pseudoglioma]) (eg, Norrie disease), full gene sequence NDUFA1 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 1, 7.5kDa) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequence NDUFAF2 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, assembly factor 2) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequence NDUFS4 (NADH dehydrogenase [ubiquinone] Fe-S protein 4, 18kDa [NADH-coenzyme Q reductase]) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequence NIPA1 (non- imprinted in Prader-Willi/Angelman syndrome 1) (eg, spastic paraplegia), full gene sequence NLGN4X (neuroligin 4, X-linked) (eg, autism spectrum disorders), duplication/deletion analysis NPC2 (Niemann-Pick disease, type C2 [epididymal secretory protein E1]) (eg, Niemann-Pick disease type C2), full gene sequence NR0B1 (nuclear receptor subfamily 0, group B, member 1) (eg, congenital adrenal hypoplasia), full gene sequence PDX1 (pancreatic and duodenal homeobox 1) (eg, maturity- onset diabetes of the young [MODY]), full gene sequence PHOX2B (paired-like homeobox 2b) (eg, congenital central hypoventilation syndrome), full gene sequence PLP1 (proteolipid protein 1) (eg, Pelizaeus- Merzbacher disease, spastic paraplegia), duplication/deletion analysis PQBP1 (polyglutamine binding protein 1) (eg, Renpenning syndrome), duplication/deletion analysis PRNP (prion protein) (eg, genetic prion disease), full gene sequence PROP1 (PROP paired-like homeobox 1) (eg, combined pituitary hormone deficiency), full gene sequence PRPH2 (peripherin 2 [retinal degeneration, slow]) (eg, retinitis pigmentosa), full gene sequence PRSS1 (protease, serine, 1 [trypsin 1]) (eg, hereditary pancreatitis), full gene sequence RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1) (eg, LEOPARD syndrome), targeted sequence analysis (eg, exons 7, 12, 14, 17) RET (ret proto-oncogene) (eg, multiple endocrine neoplasia, type 2B and familial medullary thyroid carcinoma), common variants (eg, M918T, 2647_2648delinsTT, A883F) RHO (rhodopsin) (eg, retinitis pigmentosa), full gene sequence RP1 (retinitis pigmentosa 1) (eg, retinitis pigmentosa), full gene sequence SCN1B (sodium channel, voltage-gated, type I, beta) (eg, Brugada syndrome),

full gene sequence SCO2 (SCO cytochrome oxidase deficient homolog

2 [SCO1L]) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequence SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) (eg, hereditary paraganglioma- pheochromocytoma syndrome), duplication/deletion analysis SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein) (eg, hereditary paraganglioma), full gene sequence SGCG (sarcoglycan, gamma [35kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), duplication/deletion analysis SH2D1A (SH2 domain containing 1A) (eg, X-linked lymphoproliferative syndrome), full gene sequence SLC16A2 (solute carrier family 16, member 2 [thyroid hormone transporter]) (eg, specific thyroid hormone cell transporter deficiency, Allan-Herndon-Dudley syndrome), duplication/deletion analysis SLC25A20 (solute carrier family 25 [carnitine/acylcarnitine translocase], member 20) (eg, carnitine-acylcarnitine translocase deficiency), duplication/deletion analysis SLC25A4 (solute carrier family 25 [mitochondrial carrier; adenine nucleotide translocator], member 4) (eg, progressive external ophthalmoplegia), full gene sequence SOD1 (superoxide dismutase 1, soluble) (eg, amyotrophic lateral sclerosis), full gene sequence SPINK1 (serine peptidase inhibitor, Kazal type 1) (eg, hereditary pancreatitis), full gene sequence STK11 (serine/threonine kinase 11) (eg, Peutz-Jeghers syndrome), duplication/deletion analysis TACO1 (translational activator of mitochondrial encoded cytochrome c oxidase I) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequence THAP1 (THAP domain containing, apoptosis associated protein 1) (eg, torsion dystonia), full gene sequence TOR1A (torsin family 1, member A [torsin A]) (eg, torsion dystonia), full gene sequence TTPA (tocopherol [alpha] transfer protein) (eg, ataxia), full gene sequence

TTR (transthyretin) (eg, familial transthyretin amyloidosis), full gene sequence TWIST1 (twist homolog 1 [Drosophila]) (eg, Saethre-Chotzen syndrome), full gene sequence TYR (tyrosinase [oculocutaneous albinism IA]) (eg, oculocutaneous albinism IA), full gene sequence UGT1A1

(UDP glucuronosyltransferase 1 family, polypeptide A1) (eg, hereditary unconjugated hyperbilirubinemia [Crigler-Najjar syndrome]) full gene sequence USH1G (Usher syndrome 1G [autosomal recessive]) (eg, Usher syndrome, type 1), full gene sequence VHL (von Hippel-Lindau tumor suppressor) (eg, von Hippel-Lindau familial cancer syndrome), full gene sequence VWF (von Willebrand factor) (eg, von Willebrand disease type 1C), targeted sequence analysis (eg, exons 26, 27, 37) ZEB2 (zinc finger E-box binding homeobox 2) (eg, Mowat-Wilson syndrome), duplication/ deletion analysis ZNF41 (zinc finger protein 41) (eg, X-linked intellectual disability 89), full gene sequence

full gene sequenceNDUFS4 (NADH dehydrogenase [ubiquinone]

Fe-S protein 4, 18kDa [NADH-coenzyme Q reductase]) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequenceNIPA1 (non-imprinted in Prader-Willi/Angelman syndrome 1) (eg, spastic paraplegia), full gene sequenceNLGN4X (neuroligin 4, X-linked)

(eg, autism spectrum disorders), duplication/deletion analysisNPC2 (Niemann-Pick disease, type C2 [epididymal secretory protein E1]) (eg, Niemann-Pick disease type C2), full gene sequenceNR0B1 (nuclear receptor subfamily 0, group B, member 1) (eg, congenital adrenal hypoplasia), full gene sequencePDX1 (pancreatic and duodenal homeobox 1) (eg, maturity-onset diabetes of the young [MODY]), full gene sequencePHOX2B (paired-like homeobox 2b) (eg, congenital central hypoventilation syndrome), full gene sequencePLP1 (proteolipid protein 1) (eg, Pelizaeus-Merzbacher disease, spastic paraplegia), duplication/deletion analysisPQBP1 (polyglutamine binding protein 1) (eg, Renpenning syndrome), duplication/deletion analysisPRNP (prion protein) (eg, genetic prion disease), full gene sequencePROP1 (PROP paired-like homeobox 1) (eg, combined pituitary hormone deficiency), full gene sequencePRPH2 (peripherin 2 [retinal degeneration, slow]) (eg, retinitis pigmentosa), full gene sequencePRSS1 (protease, serine,

1 [trypsin 1]) (eg, hereditary pancreatitis), full gene sequenceRAF1

(v-raf-1 murine leukemia viral oncogene homolog 1) (eg, LEOPARD syndrome), targeted sequence analysis (eg, exons 7, 12, 14, 17)RET (ret proto-oncogene) (eg, multiple endocrine neoplasia, type 2B and familial medullary thyroid carcinoma), common variants (eg, M918T,

2647_2648delinsTT, A883F)RHO (rhodopsin) (eg, retinitis pigmentosa), full gene sequenceRP1 (retinitis pigmentosa 1) (eg, retinitis pigmentosa), full gene sequenceSCN1B (sodium channel, voltage-gated, type I, beta) (eg, Brugada syndrome), full gene sequenceSCO2 (SCO cytochrome oxidase deficient homolog 2 [SCO1L]) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequenceSDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) (eg, hereditary paraganglioma-pheochromocytoma syndrome),

duplication/deletion analysisSDHD (succinate dehydrogenase complex,

subunit D, integral membrane protein) (eg, hereditary paraganglioma), full gene sequenceSGCG (sarcoglycan, gamma [35kDa dystrophin- associated glycoprotein]) (eg, limb-girdle muscular dystrophy), duplication/deletion analysisSH2D1A (SH2 domain containing 1A) (eg, X-linked lymphoproliferative syndrome), full gene sequenceSLC16A2 (solute carrier family 16, member 2 [thyroid hormone transporter]) (eg, specific thyroid hormone cell transporter deficiency, Allan-Herndon- Dudley syndrome), duplication/deletion analysisSLC25A20 (solute carrier family 25 [carnitine/acylcarnitine translocase], member 20) (eg, carnitine-acylcarnitine translocase deficiency), duplication/deletion analysisSLC25A4 (solute carrier family 25 [mitochondrial carrier; adenine nucleotide translocator], member 4) (eg, progressive external ophthalmoplegia), full gene sequenceSOD1 (superoxide dismutase 1, soluble) (eg, amyotrophic lateral sclerosis), full gene sequenceSPINK1

(serine peptidase inhibitor, Kazal type 1) (eg, hereditary pancreatitis), full

gene sequenceSTK11 (serine/threonine kinase 11) (eg, Peutz-Jeghers syndrome), duplication/deletion analysisTACO1 (translational activator of mitochondrial encoded cytochrome c oxidase I) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequenceTHAP1 (THAP domain containing, apoptosis associated protein 1) (eg, torsion dystonia), full gene sequenceTOR1A (torsin family 1, member A [torsin A]) (eg, torsion dystonia), full gene sequenceTTPA (tocopherol [alpha] transfer protein) (eg, ataxia), full gene sequenceTTR (transthyretin) (eg, familial transthyretin amyloidosis), full gene sequenceTWIST1 (twist homolog 1 [Drosophila]) (eg, Saethre-Chotzen syndrome),

full gene sequenceTYR (tyrosinase [oculocutaneous albinism IA])

(eg, oculocutaneous albinism IA), full gene sequenceUGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1) (eg, hereditary unconjugated hyperbilirubinemia [Crigler-Najjar syndrome]) full gene sequenceUSH1G (Usher syndrome 1G [autosomal recessive]) (eg, Usher syndrome, type 1), full gene sequenceVHL (von Hippel-Lindau tumor suppressor) (eg, von Hippel-Lindau familial cancer syndrome), full gene sequenceVWF (von Willebrand factor) (eg, von Willebrand disease type 1C), targeted sequence analysis (eg, exons 26, 27, 37)ZEB2 (zinc finger E-box binding homeobox 2) (eg, Mowat-Wilson syndrome), duplication/ deletion analysisZNF41 (zinc finger protein 41) (eg, X-linked mental retardation 89), full gene sequence

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory

81405

Molecular pathology procedure, Level 6 (eg, analysis of 6-10 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 11-25 exons, regionally targeted cytogenomic array analysis) ABCD1 (ATP-binding cassette, sub- family D [ALD], member 1) (eg, adrenoleukodystrophy), full gene sequence ACADS (acyl-CoA dehydrogenase, C-2 to C-3 short chain) (eg, short chain acyl-CoA dehydrogenase deficiency), full gene sequence ACTA2 (actin, alpha 2, smooth muscle, aorta) (eg, thoracic aortic aneurysms and aortic dissections), full gene sequence ACTC1 (actin, alpha, cardiac muscle 1) (eg, familial hypertrophic cardiomyopathy), full gene sequence ANKRD1 (ankyrin repeat domain 1) (eg, dilated cardiomyopathy), full gene sequence APTX (aprataxin) (eg, ataxia with oculomotor apraxia 1), full gene sequence ARSA (arylsulfatase A) (eg, arylsulfatase A deficiency), full gene sequence BCKDHA (branched chain keto acid dehydrogenase E1, alpha polypeptide) (eg, maple syrup urine disease, type 1A), full gene sequence BCS1L (BCS1-like

(eg, early infantile epileptic encephalopathy), duplication/ deletion analysis CHRNA4 (cholinergic receptor, nicotinic, alpha 4) (eg, nocturnal frontal lobe epilepsy), full gene sequence CHRNB2 (cholinergic receptor, nicotinic, beta 2 [neuronal]) (eg, nocturnal frontal lobe epilepsy), full gene sequence COX10 (COX10 homolog, cytochrome c oxidase assembly protein)

(eg, mitochondrial respiratory chain complex IV deficiency), full gene sequence COX15 (COX15 homolog, cytochrome c oxidase assembly protein) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequence CPOX (coproporphyrinogen oxidase) (eg, hereditary coproporphyria), full gene sequence CTRC (chymotrypsin C) (eg, hereditary pancreatitis), full gene sequence CYP11B1 (cytochrome P450, family 11, subfamily B, polypeptide 1) (eg, congenital adrenal hyperplasia), full gene sequence CYP17A1 (cytochrome P450, family 17, subfamily A, polypeptide 1) (eg, congenital adrenal hyperplasia), full gene sequence CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide2) (eg, steroid 21-hydroxylase isoform, congenital adrenal hyperplasia), full gene sequence Cytogenomic constitutional targeted microarray analysis of chromosome 22q13 by interrogation of genomic regions for copy number and single nucleotide polymorphism (SNP) variants for chromosomal abnormalities (When performing cytogenomic [genome-wide] analysis for constitutional chromosomal abnormalities, see 81228, 81229, 81349) (Do not report analyte-specific molecular pathology procedures separately when the specific analytes are

included as part of the microarray analysis of chromosome 22q13) (Do not report 88271 when performing cytogenomic microarray analysis) DBT (dihydrolipoamide branched chain transacylase

E2) (eg, maple syrup urine disease, type 2), duplication/deletion analysis DCX (doublecortin) (eg, X-linked lissencephaly), full gene sequence DES (desmin) (eg, myofibrillar myopathy), full gene sequence DFNB59 (deafness, autosomal recessive 59) (eg, autosomal recessive nonsyndromic hearing impairment), full gene sequence DGUOK (deoxyguanosine kinase) (eg, hepatocerebral mitochondrial DNA depletion syndrome), full gene sequence DHCR7 (7-dehydrocholesterol reductase)

(eg, Smith-Lemli-Opitz syndrome), full gene sequence EIF2B2 (eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa) (eg, leukoencephalopathy with vanishing white matter), full

gene sequence EMD (emerin) (eg, Emery-Dreifuss muscular dystrophy), full gene sequence ENG (endoglin) (eg, hereditary hemorrhagic telangiectasia, type 1), duplication/deletion analysis EYA1 (eyes absent homolog 1 [Drosophila]) (eg, branchio-oto-renal [BOR] spectrum disorders), duplication/deletion analysis FGFR1 (fibroblast growth factor receptor 1) (eg, Kallmann syndrome 2), full gene sequence FH (fumarate hydratase) (eg, fumarate hydratase deficiency, hereditary leiomyomatosis with renal cell cancer),

full gene sequence FKTN (fukutin) (eg, limb-girdle muscular dystrophy [LGMD] type 2M or 2L), full gene sequence FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1) (eg, X-linked intellectual disability 9), duplication/deletion analysis GABRG2 (gamma-aminobutyric acid [GABA] A receptor, gamma 2) (eg, generalized epilepsy with febrile seizures), full gene sequence GCH1 (GTP cyclohydrolase 1)

Molecular pathology procedure, Level 6 (eg, analysis of 6-10 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 11-25 exons, regionally targeted cytogenomic array analysis)ABCD1 (ATP-binding cassette, sub- family D [ALD], member 1) (eg, adrenoleukodystrophy), full gene sequenceACADS (acyl-CoA dehydrogenase, C-2 to C-3 short chain) (eg, short chain acyl-CoA dehydrogenase deficiency), full gene sequenceACTA2 (actin, alpha 2, smooth muscle, aorta) (eg, thoracic aortic aneurysms and aortic dissections), full gene sequenceACTC1 (actin, alpha, cardiac muscle 1) (eg, familial hypertrophic cardiomyopathy), full gene sequenceANKRD1 (ankyrin repeat domain 1) (eg, dilated cardiomyopathy), full gene sequenceAPTX (aprataxin) (eg, ataxia with oculomotor apraxia 1), full gene sequenceARSA (arylsulfatase A) (eg, arylsulfatase A deficiency), full gene sequenceBCKDHA (branched chain keto acid dehydrogenase E1, alpha polypeptide) (eg, maple syrup urine disease, type 1A), full gene sequenceBCS1L (BCS1-like

[S. cerevisiae]) (eg, Leigh syndrome, mitochondrial complex III deficiency, GRACILE syndrome), full gene sequenceBMPR2 (bone morphogenetic protein receptor, type II [serine/threonine kinase]) (eg, heritable pulmonary arterial hypertension), duplication/ deletion analysisCASQ2 (calsequestrin 2 [cardiac muscle]) (eg, catecholaminergic polymorphic ventricular tachycardia), full gene sequenceCASR (calcium-sensing receptor) (eg, hypocalcemia), full gene sequenceCDKL5 (cyclin-dependent kinase-like 5) (eg, early infantile epileptic encephalopathy), duplication/deletion analysisCHRNA4 (cholinergic receptor, nicotinic, alpha 4) (eg, nocturnal frontal lobe epilepsy), full gene sequenceCHRNB2 (cholinergic receptor, nicotinic, beta 2 [neuronal]) (eg, nocturnal frontal lobe epilepsy), full gene sequenceCOX10 (COX10 homolog, cytochrome c oxidase assembly protein) (eg, mitochondrial respiratory chain complex IV deficiency), full

gene sequenceCOX15 (COX15 homolog, cytochrome c oxidase assembly protein) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequenceCPOX (coproporphyrinogen oxidase) (eg, hereditary coproporphyria), full gene sequenceCTRC (chymotrypsin C) (eg, hereditary pancreatitis), full gene sequenceCYP11B1 (cytochrome P450, family 11, subfamily

B, polypeptide 1) (eg, congenital adrenal hyperplasia), full gene sequenceCYP17A1 (cytochrome P450, family 17, subfamily A, polypeptide 1) (eg, congenital adrenal hyperplasia), full gene sequenceCYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide2) (eg, steroid 21-hydroxylase isoform, congenital adrenal hyperplasia), full gene sequenceCytogenomic constitutional targeted microarray analysis of chromosome 22q13 by interrogation of genomic regions for copy number and single nucleotide polymorphism (SNP) variants for chromosomal abnormalities(When performing cytogenomic [genome-wide]

analysis for constitutional chromosomal abnormalities, see 81228, 81229, 81349)(Do not report analyte-specific molecular pathology procedures separately when the specific analytes are included as part of the microarray analysis of chromosome 22q13)(Do

not report 88271 when performing cytogenomic microarray analysis)DBT (dihydrolipoamide branched chain transacylase E2) (eg, maple syrup urine disease, type 2), duplication/deletion analysisDCX (doublecortin) (eg, X-linked lissencephaly), full gene sequenceDES (desmin) (eg, myofibrillar myopathy), full gene sequenceDFNB59 (deafness, autosomal recessive 59) (eg, autosomal recessive nonsyndromic hearing impairment), full gene sequenceDGUOK (deoxyguanosine kinase) (eg, hepatocerebral mitochondrial DNA depletion syndrome), full gene sequenceDHCR7 (7-dehydrocholesterol reductase)

(eg, Smith-Lemli-Opitz syndrome), full gene sequenceEIF2B2 (eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa) (eg, leukoencephalopathy with vanishing white matter), full gene sequenceEMD (emerin) (eg, Emery-Dreifuss muscular dystrophy), full gene sequenceENG (endoglin) (eg, hereditary hemorrhagic telangiectasia, type 1), duplication/deletion analysisEYA1 (eyes absent homolog 1 [Drosophila]) (eg, branchio-oto-renal [BOR] spectrum disorders), duplication/deletion analysisFGFR1 (fibroblast growth factor receptor 1) (eg, Kallmann syndrome

2), full gene sequenceFH (fumarate hydratase) (eg, fumarate hydratase deficiency, hereditary leiomyomatosis with renal cell cancer), full gene sequenceFKTN (fukutin) (eg, limb- girdle muscular dystrophy [LGMD] type 2M or 2L), full gene sequenceFTSJ1 (FtsJ RNA methyltransferase homolog 1 [E. coli]) (eg, X-linked mental retardation 9), duplication/deletion

analysisGABRG2 (gamma-aminobutyric acid [GABA] A receptor, gamma 2) (eg, generalized epilepsy with febrile seizures), full

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory (continued)

81405

(eg, autosomal dominant dopa-responsive dystonia), full gene sequence GDAP1 (ganglioside-induced differentiation-

associated protein 1) (eg, Charcot-Marie-Tooth disease), full gene sequence GFAP (glial fibrillary acidic protein) (eg, Alexander disease), full gene sequence GHR (growth hormone receptor) (eg, Laron syndrome), full gene sequence GHRHR (growth hormone releasing hormone receptor) (eg, growth hormone deficiency), full gene sequence GLA (galactosidase, alpha) (eg, Fabry disease), full gene sequence HNF1A (HNF1 homeobox

A) (eg, maturity-onset diabetes of the young [MODY]), full gene sequence HNF1B (HNF1 homeobox B) (eg, maturity-onset diabetes of the young [MODY]), full gene sequence HTRA1 (HtrA serine peptidase 1) (eg, macular degeneration), full gene sequence

IDS (iduronate 2-sulfatase) (eg, mucopolysacchridosis, type II), full gene sequence IL2RG (interleukin 2 receptor, gamma) (eg, X-linked severe combined immunodeficiency), full gene sequence ISPD (isoprenoid synthase domain containing) (eg,

muscle-eye-brain disease, Walker-Warburg syndrome), full gene sequence KRAS (Kirsten rat sarcoma viral oncogene homolog) (eg, Noonan syndrome), full gene sequence LAMP2 (lysosomal- associated membrane protein 2) (eg, Danon disease), full

gene sequence LDLR (low density lipoprotein receptor) (eg, familial hypercholesterolemia), duplication/deletion analysis MEN1 (multiple endocrine neoplasia I) (eg, multiple endocrine neoplasia type 1, Wermer syndrome), full gene sequence MMAA (methylmalonic aciduria [cobalamine deficiency] type A) (eg, MMAA-related methylmalonic acidemia), full gene sequence MMAB (methylmalonic aciduria [cobalamine deficiency] type B) (eg, MMAA-related methylmalonic acidemia), full gene sequence MPI (mannose phosphate isomerase) (eg, congenital disorder of

glycosylation 1b), full gene sequence MPV17 (MpV17 mitochondrial inner membrane protein) (eg, mitochondrial DNA depletion syndrome), full gene sequence MPZ (myelin protein zero) (eg, Charcot-Marie-Tooth), full gene sequence MTM1 (myotubularin

1) (eg, X-linked centronuclear myopathy), duplication/deletion analysis MYL2 (myosin, light chain 2, regulatory, cardiac, slow) (eg, familial hypertrophic cardiomyopathy), full gene sequence MYL3 (myosin, light chain 3, alkali, ventricular, skeletal, slow) (eg, familial hypertrophic cardiomyopathy), full gene sequence MYOT (myotilin) (eg, limb-girdle muscular dystrophy), full gene sequence NDUFS7 (NADH dehydrogenase [ubiquinone] Fe-S protein 7, 20kDa [NADH-coenzyme Q reductase]) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequence

NDUFS8 (NADH dehydrogenase [ubiquinone] Fe-S protein 8, 23kDa [NADH-coenzyme Q reductase]) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequence NDUFV1 (NADH dehydrogenase [ubiquinone] flavoprotein 1, 51kDa)

(eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequence NEFL (neurofilament, light polypeptide) (eg, Charcot-Marie-Tooth), full gene sequence NF2 (neurofibromin 2 [merlin]) (eg, neurofibromatosis, type 2), duplication/deletion analysis NLGN3 (neuroligin 3) (eg, autism spectrum disorders), full gene sequence NLGN4X (neuroligin 4, X-linked) (eg, autism

spectrum disorders), full gene sequence NPHP1 (nephronophthisis 1 [juvenile]) (eg, Joubert syndrome), deletion analysis, and duplication analysis, if performed NPHS2 (nephrosis 2, idiopathic, steroid-resistant [podocin]) (eg, steroid-resistant nephrotic syndrome), full gene sequence NSD1 (nuclear receptor binding SET domain protein 1) (eg, Sotos syndrome), duplication/deletion analysis OTC (ornithine carbamoyltransferase) (eg, ornithine transcarbamylase deficiency), full gene sequence PAFAH1B1 (platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 [45kDa]) (eg, lissencephaly, Miller-Dieker syndrome), duplication/ deletion analysis PARK2 (Parkinson protein 2, E3 ubiquitin protein ligase [parkin]) (eg, Parkinson disease), duplication/deletion analysis PCCA (propionyl CoA carboxylase, alpha polypeptide) (eg, propionic acidemia, type 1), duplication/deletion analysis PCDH19 (protocadherin 19) (eg, epileptic encephalopathy), full gene sequence PDHA1 (pyruvate dehydrogenase [lipoamide] alpha 1) (eg, lactic acidosis), duplication/deletion analysis PDHB (pyruvate dehydrogenase [lipoamide] beta) (eg, lactic acidosis), full gene sequence PINK1 (PTEN induced putative kinase 1)

(eg, Parkinson disease), full gene sequence PKLR (pyruvate kinase, liver and RBC) (eg, pyruvate kinase deficiency), full gene sequence PLP1 (proteolipid protein 1) (eg, Pelizaeus-Merzbacher disease, spastic paraplegia), full gene sequence POU1F1 (POU class 1 homeobox 1) (eg, combined pituitary hormone deficiency), full gene sequence PRX (periaxin) (eg, Charcot-Marie-Tooth disease), full gene sequence PQBP1 (polyglutamine binding

gene sequenceGCH1 (GTP cyclohydrolase 1) (eg, autosomal dominant dopa-responsive dystonia), full gene sequenceGDAP1 (ganglioside-induced differentiation-associated protein 1)

(eg, Charcot-Marie-Tooth disease), full gene sequenceGFAP (glial fibrillary acidic protein) (eg, Alexander disease), full gene sequenceGHR (growth hormone receptor) (eg, Laron syndrome), full gene sequenceGHRHR (growth hormone releasing

hormone receptor) (eg, growth hormone deficiency), full gene sequenceGLA (galactosidase, alpha) (eg, Fabry disease), full gene sequenceHNF1A (HNF1 homeobox A) (eg, maturity-onset diabetes of the young [MODY]), full gene sequenceHNF1B (HNF1 homeobox B) (eg, maturity-onset diabetes of the young [MODY]), full gene sequenceHTRA1 (HtrA serine peptidase 1) (eg, macular degeneration), full gene sequenceIDS (iduronate 2-sulfatase) (eg, mucopolysacchridosis, type II), full gene sequenceIL2RG (interleukin 2 receptor, gamma) (eg, X-linked severe combined immunodeficiency), full gene sequenceISPD (isoprenoid synthase domain containing) (eg, muscle-eye-brain disease,

Walker-Warburg syndrome), full gene sequenceKRAS (Kirsten rat sarcoma viral oncogene homolog) (eg, Noonan syndrome), full gene sequenceLAMP2 (lysosomal-associated membrane protein 2) (eg, Danon disease), full gene sequenceLDLR (low density lipoprotein receptor) (eg, familial hypercholesterolemia), duplication/deletion analysisMEN1 (multiple endocrine neoplasia I) (eg, multiple endocrine neoplasia type 1, Wermer syndrome), full gene sequenceMMAA (methylmalonic aciduria [cobalamine deficiency] type A) (eg, MMAA-related methylmalonic acidemia), full gene sequenceMMAB (methylmalonic aciduria [cobalamine deficiency] type B) (eg, MMAA-related methylmalonic

acidemia), full gene sequenceMPI (mannose phosphate isomerase) (eg, congenital disorder of glycosylation 1b), full gene sequenceMPV17 (MpV17 mitochondrial inner membrane protein) (eg, mitochondrial DNA depletion syndrome), full gene

sequenceMPZ (myelin protein zero) (eg, Charcot-Marie-Tooth), full gene sequenceMTM1 (myotubularin 1) (eg, X-linked centronuclear myopathy), duplication/deletion analysisMYL2 (myosin, light

chain 2, regulatory, cardiac, slow) (eg, familial hypertrophic cardiomyopathy), full gene sequenceMYL3 (myosin, light chain 3, alkali, ventricular, skeletal, slow) (eg, familial hypertrophic cardiomyopathy), full gene sequenceMYOT (myotilin) (eg, limb- girdle muscular dystrophy), full gene sequenceNDUFS7 (NADH dehydrogenase [ubiquinone] Fe-S protein 7, 20kDa [NADH- coenzyme Q reductase]) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequenceNDUFS8 (NADH dehydrogenase [ubiquinone] Fe-S protein 8, 23kDa [NADH- coenzyme Q reductase]) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequenceNDUFV1 (NADH dehydrogenase [ubiquinone] flavoprotein 1, 51kDa) (eg,

Leigh syndrome, mitochondrial complex I deficiency), full gene sequenceNEFL (neurofilament, light polypeptide) (eg, Charcot-Marie-Tooth), full gene sequenceNF2 (neurofibromin 2 [merlin]) (eg, neurofibromatosis, type 2), duplication/deletion analysisNLGN3 (neuroligin 3) (eg, autism spectrum disorders),

full gene sequenceNLGN4X (neuroligin 4, X-linked) (eg, autism spectrum disorders), full gene sequenceNPHP1 (nephronophthisis 1 [juvenile]) (eg, Joubert syndrome), deletion analysis, and duplication analysis, if performedNPHS2 (nephrosis 2, idiopathic, steroid-resistant [podocin]) (eg, steroid-resistant nephrotic syndrome), full gene sequenceNSD1 (nuclear receptor binding SET domain protein 1) (eg, Sotos syndrome), duplication/deletion analysisOTC (ornithine carbamoyltransferase) (eg, ornithine transcarbamylase deficiency), full gene sequencePAFAH1B1 (platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 [45kDa]) (eg, lissencephaly, Miller-Dieker syndrome), duplication/ deletion analysisPARK2 (Parkinson protein 2, E3 ubiquitin

protein ligase [parkin]) (eg, Parkinson disease), duplication/ deletion analysisPCCA (propionyl CoA carboxylase, alpha polypeptide) (eg, propionic acidemia, type 1), duplication/ deletion analysisPCDH19 (protocadherin 19) (eg, epileptic encephalopathy), full gene sequencePDHA1 (pyruvate dehydrogenase [lipoamide] alpha 1) (eg, lactic acidosis), duplication/deletion analysisPDHB (pyruvate dehydrogenase [lipoamide] beta) (eg, lactic acidosis), full gene sequencePINK1 (PTEN induced putative kinase 1) (eg, Parkinson disease), full gene sequencePKLR (pyruvate kinase, liver and RBC) (eg, pyruvate kinase deficiency), full gene sequencePLP1 (proteolipid protein 1) (eg, Pelizaeus-Merzbacher disease, spastic paraplegia), full gene sequencePOU1F1 (POU class 1 homeobox 1) (eg, combined pituitary hormone deficiency), full gene sequencePRX

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory (continued)

81405

protein 1) (eg, Renpenning syndrome), full gene sequence PSEN1 (presenilin 1) (eg, Alzheimer disease), full gene sequence RAB7A (RAB7A, member RAS oncogene family) (eg, Charcot-Marie-Tooth disease), full gene sequence RAI1 (retinoic acid induced 1) (eg, Smith-Magenis syndrome), full gene sequence REEP1 (receptor accessory protein 1) (eg, spastic paraplegia), full gene sequence RET (ret proto-oncogene) (eg, multiple endocrine neoplasia,

type 2A and familial medullary thyroid carcinoma), targeted sequence analysis (eg, exons 10, 11, 13-16) RPS19 (ribosomal protein S19) (eg, Diamond-Blackfan anemia), full gene sequence RRM2B (ribonucleotide reductase M2 B [TP53 inducible]) (eg, mitochondrial DNA depletion), full gene sequence SCO1 (SCO cytochrome oxidase deficient homolog 1) (eg, mitochondrial

respiratory chain complex IV deficiency), full gene sequence SDHB (succinate dehydrogenase complex, subunit B, iron sulfur) (eg, hereditary paraganglioma), full gene sequence SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) (eg, hereditary paraganglioma-pheochromocytoma syndrome), full gene sequence SGCA (sarcoglycan, alpha [50kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), full gene sequence SGCB (sarcoglycan, beta [43kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), full gene sequence SGCD (sarcoglycan, delta [35kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), full gene sequence SGCE (sarcoglycan, epsilon)

(eg, myoclonic dystonia), duplication/deletion analysis SGCG (sarcoglycan, gamma [35kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), full gene sequence SHOC2 (soc-2 suppressor of clear homolog) (eg, Noonan-like syndrome with loose anagen hair), full gene sequence SHOX (short

stature homeobox) (eg, Langer mesomelic dysplasia), full gene sequence SIL1 (SIL1 homolog, endoplasmic reticulum chaperone [S. cerevisiae]) (eg, ataxia), full gene sequence SLC2A1 (solute carrier family 2 [facilitated glucose transporter], member 1) (eg, glucose transporter type 1 [GLUT 1] deficiency syndrome), full gene sequence SLC16A2 (solute carrier family 16, member 2 [thyroid

hormone transporter]) (eg, specific thyroid hormone cell transporter deficiency, Allan-Herndon-Dudley syndrome), full gene sequence SLC22A5 (solute carrier family 22 [organic cation/carnitine transporter], member 5) (eg, systemic primary carnitine deficiency), full gene sequence SLC25A20 (solute carrier family 25 [carnitine/ acylcarnitine translocase], member 20) (eg, carnitine-acylcarnitine translocase deficiency), full gene sequence SMAD4 (SMAD family member 4) (eg, hemorrhagic telangiectasia syndrome, juvenile polyposis), duplication/deletion analysis SPAST (spastin) (eg, spastic paraplegia), duplication/deletion analysis SPG7 (spastic paraplegia 7 [pure and complicated autosomal recessive])

(eg, spastic paraplegia), duplication/deletion analysis SPRED1 (sprouty-related, EVH1 domain containing 1) (eg, Legius syndrome), full gene sequence STAT3 (signal transducer and activator of transcription 3 [acute-phase response factor]) (eg, autosomal dominant hyper-IgE syndrome), targeted sequence analysis (eg, exons 12, 13, 14, 16, 17, 20, 21) STK11 (serine/threonine kinase 11) (eg, Peutz-Jeghers syndrome), full gene sequence SURF1 (surfeit 1) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequence TARDBP (TAR DNA binding protein) (eg, amyotrophic lateral sclerosis), full gene sequence TBX5 (T-box 5) (eg, Holt-Oram syndrome), full gene sequence TCF4 (transcription factor 4) (eg, Pitt-Hopkins syndrome), duplication/deletion analysis TGFBR1 (transforming growth factor, beta receptor 1) (eg, Marfan syndrome), full gene sequence TGFBR2 (transforming growth factor, beta receptor 2) (eg, Marfan syndrome), full gene sequence THRB (thyroid hormone receptor, beta) (eg, thyroid hormone resistance, thyroid hormone beta receptor deficiency), full gene sequence or targeted sequence analysis of >5 exons TK2 (thymidine kinase 2, mitochondrial) (eg, mitochondrial DNA depletion syndrome), full gene sequence TNNC1 (troponin C type 1 [slow]) (eg, hypertrophic cardiomyopathy or dilated cardiomyopathy), full gene sequence TNNI3 (troponin I, type 3 [cardiac]) (eg, familial hypertrophic cardiomyopathy), full gene sequence TPM1 (tropomyosin 1

[alpha]) (eg, familial hypertrophic cardiomyopathy), full gene sequence TSC1 (tuberous sclerosis 1) (eg, tuberous sclerosis), duplication/deletion analysis TYMP (thymidine phosphorylase) (eg, mitochondrial DNA depletion syndrome), full gene sequence VWF (von Willebrand factor) (eg, von Willebrand disease type 2N), targeted sequence analysis (eg, exons 18-20, 23-25) WT1 (Wilms tumor 1) (eg, Denys-Drash syndrome, familial Wilms tumor), full gene sequence ZEB2 (zinc finger E-box binding homeobox 2) (eg, Mowat-Wilson syndrome), full gene sequence

(periaxin) (eg, Charcot-Marie-Tooth disease), full gene sequencePQBP1 (polyglutamine binding protein 1) (eg, Renpenning syndrome), full gene sequencePSEN1 (presenilin 1) (eg, Alzheimer disease), full gene sequenceRAB7A (RAB7A, member RAS oncogene family) (eg, Charcot-Marie-Tooth disease), full gene sequenceRAI1 (retinoic acid induced 1) (eg, Smith-Magenis syndrome), full gene sequenceREEP1 (receptor accessory protein 1) (eg, spastic paraplegia), full gene sequenceRET (ret proto- oncogene) (eg, multiple endocrine neoplasia, type 2A and familial medullary thyroid carcinoma), targeted sequence analysis (eg, exons 10, 11, 13-16)RPS19 (ribosomal protein S19) (eg, Diamond- Blackfan anemia), full gene sequenceRRM2B (ribonucleotide reductase M2 B [TP53 inducible]) (eg, mitochondrial DNA depletion), full gene sequenceSCO1 (SCO cytochrome oxidase deficient homolog 1) (eg, mitochondrial respiratory chain complex

IV deficiency), full gene sequenceSDHB (succinate dehydrogenase

complex, subunit B, iron sulfur) (eg, hereditary paraganglioma), full gene sequenceSDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) (eg, hereditary paraganglioma-pheochromocytoma syndrome), full gene

sequenceSGCA (sarcoglycan, alpha [50kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), full gene sequenceSGCB (sarcoglycan, beta [43kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), full gene sequenceSGCD (sarcoglycan, delta [35kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), full gene sequenceSGCE (sarcoglycan, epsilon) (eg, myoclonic dystonia), duplication/deletion analysisSGCG (sarcoglycan, gamma [35kDa dystrophin-associated glycoprotein]) (eg, limb-girdle muscular dystrophy), full gene sequenceSHOC2 (soc-2 suppressor of clear homolog) (eg, Noonan-like syndrome with loose anagen hair),

full gene sequenceSHOX (short stature homeobox) (eg, Langer

mesomelic dysplasia), full gene sequenceSIL1 (SIL1 homolog, endoplasmic reticulum chaperone [S. cerevisiae]) (eg, ataxia), full gene sequenceSLC2A1 (solute carrier family 2 [facilitated glucose transporter], member 1) (eg, glucose transporter type 1 [GLUT 1] deficiency syndrome), full gene sequenceSLC16A2 (solute carrier family 16, member 2 [thyroid hormone transporter]) (eg, specific thyroid hormone cell transporter deficiency, Allan-Herndon-Dudley syndrome), full gene sequenceSLC22A5 (solute carrier family 22 [organic cation/carnitine transporter], member 5) (eg, systemic primary carnitine deficiency), full gene sequenceSLC25A20 (solute carrier family 25 [carnitine/acylcarnitine translocase], member

20) (eg, carnitine-acylcarnitine translocase deficiency), full gene

sequenceSMAD4 (SMAD family member 4) (eg, hemorrhagic telangiectasia syndrome, juvenile polyposis), duplication/ deletion analysisSPAST (spastin) (eg, spastic paraplegia), duplication/deletion analysisSPG7 (spastic paraplegia 7 [pure and complicated autosomal recessive]) (eg, spastic paraplegia),

duplication/deletion analysisSPRED1 (sprouty-related, EVH1 domain containing 1) (eg, Legius syndrome), full gene sequenceSTAT3 (signal transducer and activator of transcription 3 [acute-phase response factor]) (eg, autosomal dominant hyper-IgE syndrome), targeted sequence analysis (eg, exons 12, 13, 14, 16, 17, 20, 21) STK11 (serine/threonine kinase 11) (eg, Peutz-Jeghers syndrome), full gene sequenceSURF1 (surfeit 1) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequenceTARDBP (TAR DNA binding protein) (eg, amyotrophic lateral sclerosis), full gene sequenceTBX5 (T-box 5) (eg, Holt-Oram syndrome), full gene sequenceTCF4 (transcription factor 4) (eg, Pitt-Hopkins syndrome), duplication/deletion analysisTGFBR1 (transforming growth factor,

beta receptor 1) (eg, Marfan syndrome), full gene sequenceTGFBR2

(transforming growth factor, beta receptor 2) (eg, Marfan syndrome), full gene sequenceTHRB (thyroid hormone receptor, beta) (eg, thyroid hormone resistance, thyroid hormone beta receptor deficiency), full gene sequence or targeted sequence analysis of

>5 exonsTK2 (thymidine kinase 2, mitochondrial) (eg, mitochondrial DNA depletion syndrome), full gene sequenceTNNC1 (troponin

C type 1 [slow]) (eg, hypertrophic cardiomyopathy or dilated cardiomyopathy), full gene sequenceTNNI3 (troponin I, type 3 [cardiac]) (eg, familial hypertrophic cardiomyopathy), full gene sequenceTPM1 (tropomyosin 1 [alpha]) (eg, familial hypertrophic cardiomyopathy), full gene sequenceTSC1 (tuberous sclerosis 1) (eg, tuberous sclerosis), duplication/deletion analysisTYMP (thymidine phosphorylase) (eg, mitochondrial DNA depletion syndrome), full gene sequenceVWF (von Willebrand factor) (eg, von Willebrand disease type 2N), targeted sequence analysis (eg, exons 18-20,

23-25)WT1 (Wilms tumor 1) (eg, Denys-Drash syndrome, familial Wilms tumor), full gene sequenceZEB2 (zinc finger E-box binding homeobox 2) (eg, Mowat-Wilson syndrome), full gene sequence

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory

81406

Molecular pathology procedure, Level 7 (eg, analysis of 11- 25 exons by DNA sequence analysis, mutation scanning or

duplication/deletion variants of 26-50 exons) ACADVL (acyl-CoA dehydrogenase, very long chain) (eg, very long chain acyl- coenzyme A dehydrogenase deficiency), full gene sequence ACTN4 (actinin, alpha 4) (eg, focal segmental glomerulosclerosis), full gene sequence AFG3L2 (AFG3 ATPase family gene 3-like 2 [S. cerevisiae]) (eg, spinocerebellar ataxia), full gene sequence

AIRE (autoimmune regulator) (eg, autoimmune polyendocrinopathy syndrome type 1), full gene sequence ALDH7A1 (aldehyde dehydrogenase 7 family, member A1) (eg, pyridoxine-dependent epilepsy), full gene sequence ANO5 (anoctamin 5) (eg, limb-girdle muscular dystrophy), full gene sequence ANOS1 (anosmin-1) (eg, Kallmann syndrome 1), full gene sequence APP (amyloid beta [A4] precursor protein) (eg, Alzheimer disease), full gene sequence ASS1 (argininosuccinate synthase 1) (eg, citrullinemia type I), full gene sequence ATL1 (atlastin GTPase 1) (eg, spastic paraplegia), full gene sequence ATP1A2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide) (eg, familial hemiplegic migraine), full gene sequence ATP7B (ATPase, Cu++ transporting, beta polypeptide) (eg, Wilson disease), full gene sequence BBS1 (Bardet-Biedl syndrome 1) (eg, Bardet-Biedl syndrome), full gene sequence BBS2 (Bardet-Biedl syndrome 2) (eg, Bardet-Biedl syndrome), full gene sequence BCKDHB (branched-chain keto acid dehydrogenase E1, beta polypeptide) (eg, maple syrup urine disease, type 1B), full gene sequence BEST1 (bestrophin 1) (eg, vitelliform macular dystrophy), full gene sequence BMPR2 (bone morphogenetic protein receptor, type II [serine/threonine kinase]) (eg, heritable pulmonary arterial hypertension), full gene sequence BRAF (B-Raf proto- oncogene, serine/threonine kinase) (eg, Noonan syndrome), full gene sequence BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 [seipin]) (eg, Berardinelli-Seip congenital lipodystrophy), full gene sequence BTK (Bruton agammaglobulinemia tyrosine kinase)

(eg, X-linked agammaglobulinemia), full gene sequence CACNB2 (calcium channel, voltage-dependent, beta 2 subunit) (eg, Brugada syndrome), full gene sequence CAPN3 (calpain 3) (eg, limb-girdle muscular dystrophy [LGMD] type 2A, calpainopathy), full gene sequence CBS (cystathionine-beta-synthase) (eg, homocystinuria, cystathionine beta-synthase deficiency), full gene sequence CDH1 (cadherin 1, type 1, E-cadherin [epithelial]) (eg, hereditary diffuse gastric cancer), full gene sequence CDKL5 (cyclin-dependent kinase-like 5) (eg, early infantile epileptic encephalopathy), full gene sequence CLCN1 (chloride channel 1, skeletal muscle) (eg, myotonia congenita), full gene sequence CLCNKB (chloride channel, voltage-sensitive Kb) (eg, Bartter syndrome 3 and 4b),

full gene sequence CNTNAP2 (contactin-associated protein- like 2) (eg, Pitt-Hopkins-like syndrome 1), full gene sequence COL6A2 (collagen, type VI, alpha 2) (eg, collagen type VI- related disorders), duplication/deletion analysis CPT1A (carnitine palmitoyltransferase 1A [liver]) (eg, carnitine palmitoyltransferase

1A [CPT1A] deficiency), full gene sequence CRB1 (crumbs homolog 1 [Drosophila]) (eg, Leber congenital amaurosis), full gene sequence CREBBP (CREB binding protein) (eg, Rubinstein-Taybi syndrome), duplication/deletion analysis DBT (dihydrolipoamide branched chain transacylase E2) (eg, maple syrup urine

disease, type 2), full gene sequence DLAT (dihydrolipoamide

S-acetyltransferase) (eg, pyruvate dehydrogenase E2 deficiency), full gene sequence DLD (dihydrolipoamide dehydrogenase) (eg, maple syrup urine disease, type III), full gene sequence DSC2 (desmocollin) (eg, arrhythmogenic right ventricular dysplasia/ cardiomyopathy 11), full gene sequence DSG2 (desmoglein 2) (eg, arrhythmogenic right ventricular dysplasia/cardiomyopathy 10), full gene sequence DSP (desmoplakin) (eg, arrhythmogenic right ventricular dysplasia/cardiomyopathy 8), full gene sequence EFHC1 (EF-hand domain [C-terminal] containing 1) (eg, juvenile myoclonic epilepsy), full gene sequence EIF2B3 (eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa) (eg, leukoencephalopathy with vanishing white matter), full gene sequence EIF2B4 (eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa) (eg, leukoencephalopathy with vanishing white matter), full gene sequence EIF2B5 (eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa) (eg, childhood ataxia with central nervous system hypomyelination/vanishing white matter), full gene sequence ENG (endoglin) (eg, hereditary hemorrhagic telangiectasia, type 1), full gene sequence EYA1 (eyes absent homolog 1 [Drosophila]) (eg, branchio-oto-renal [BOR] spectrum disorders), full gene sequence F8 (coagulation factor VIII) (eg, hemophilia A), duplication/deletion analysis FAH (fumarylacetoacetate hydrolase [fumarylacetoacetase]) (eg, tyrosinemia, type 1), full gene sequence FASTKD2

Molecular pathology procedure, Level 7 (eg, analysis of

11-25 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 26-50 exons)ACADVL (acyl-CoA dehydrogenase, very long chain) (eg, very long chain acyl-coenzyme A dehydrogenase deficiency), full gene sequenceACTN4 (actinin, alpha 4) (eg, focal segmental

glomerulosclerosis), full gene sequenceAFG3L2 (AFG3 ATPase family gene 3-like 2 [S. cerevisiae]) (eg, spinocerebellar

ataxia), full gene sequenceAIRE (autoimmune regulator) (eg, autoimmune polyendocrinopathy syndrome type 1), full gene sequenceALDH7A1 (aldehyde dehydrogenase 7 family, member A1) (eg, pyridoxine-dependent epilepsy), full gene sequenceANO5 (anoctamin 5) (eg, limb-girdle muscular dystrophy), full gene sequenceANOS1 (anosmin-1) (eg, Kallmann syndrome 1), full gene sequenceAPP (amyloid beta [A4] precursor protein) (eg, Alzheimer disease), full gene sequenceASS1 (argininosuccinate synthase

1) (eg, citrullinemia type I), full gene sequenceATL1 (atlastin GTPase 1) (eg, spastic paraplegia), full gene sequenceATP1A2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide) (eg, familial hemiplegic migraine), full gene sequenceATP7B (ATPase, Cu++ transporting, beta polypeptide) (eg, Wilson disease), full gene sequenceBBS1 (Bardet-Biedl syndrome 1) (eg, Bardet-Biedl syndrome), full gene sequenceBBS2 (Bardet-Biedl syndrome 2) (eg, Bardet-Biedl syndrome), full gene sequenceBCKDHB

(branched-chain keto acid dehydrogenase E1, beta polypeptide) (eg, maple syrup urine disease, type 1B), full gene sequenceBEST1 (bestrophin 1) (eg, vitelliform macular dystrophy), full gene sequenceBMPR2 (bone morphogenetic protein receptor, type

II [serine/threonine kinase]) (eg, heritable pulmonary arterial hypertension), full gene sequenceBRAF (B-Raf proto-oncogene, serine/threonine kinase) (eg, Noonan syndrome), full gene sequenceBSCL2 (Berardinelli-Seip congenital lipodystrophy 2 [seipin]) (eg, Berardinelli-Seip congenital lipodystrophy), full gene sequenceBTK (Bruton agammaglobulinemia tyrosine kinase)

(eg, X-linked agammaglobulinemia), full gene sequenceCACNB2 (calcium channel, voltage-dependent, beta 2 subunit) (eg, Brugada syndrome), full gene sequenceCAPN3 (calpain 3) (eg, limb-girdle muscular dystrophy [LGMD] type 2A, calpainopathy), full gene sequenceCBS (cystathionine-beta-synthase) (eg, homocystinuria, cystathionine beta-synthase deficiency), full gene sequenceCDH1 (cadherin 1, type 1, E-cadherin [epithelial]) (eg, hereditary diffuse gastric cancer), full gene sequenceCDKL5 (cyclin-dependent kinase-like 5) (eg, early infantile epileptic encephalopathy), full gene sequenceCLCN1 (chloride channel 1, skeletal muscle) (eg, myotonia congenita), full gene sequenceCLCNKB (chloride channel, voltage-sensitive Kb) (eg, Bartter syndrome 3 and 4b),

full gene sequenceCNTNAP2 (contactin-associated protein-like 2) (eg, Pitt-Hopkins-like syndrome 1), full gene sequenceCOL6A2

(collagen, type VI, alpha 2) (eg, collagen type VI-related disorders), duplication/deletion analysisCPT1A (carnitine palmitoyltransferase 1A [liver]) (eg, carnitine palmitoyltransferase 1A [CPT1A] deficiency), full gene sequenceCRB1 (crumbs homolog 1 [Drosophila]) (eg, Leber congenital amaurosis), full gene sequenceCREBBP (CREB binding protein) (eg, Rubinstein-Taybi syndrome), duplication/ deletion analysisDBT (dihydrolipoamide branched chain transacylase E2) (eg, maple syrup urine disease, type 2), full

gene sequenceDLAT (dihydrolipoamide S-acetyltransferase) (eg, pyruvate dehydrogenase E2 deficiency), full gene sequenceDLD (dihydrolipoamide dehydrogenase) (eg, maple syrup urine disease, type III), full gene sequenceDSC2 (desmocollin) (eg, arrhythmogenic right ventricular dysplasia/cardiomyopathy 11), full gene sequenceDSG2 (desmoglein 2) (eg, arrhythmogenic right ventricular dysplasia/cardiomyopathy 10), full gene sequenceDSP (desmoplakin) (eg, arrhythmogenic right ventricular dysplasia/ cardiomyopathy 8), full gene sequenceEFHC1 (EF-hand domain [C-terminal] containing 1) (eg, juvenile myoclonic epilepsy),

full gene sequenceEIF2B3 (eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa) (eg, leukoencephalopathy with vanishing white matter), full gene sequenceEIF2B4 (eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa) (eg, leukoencephalopathy with vanishing white matter), full gene sequenceEIF2B5 (eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa) (eg, childhood ataxia

with central nervous system hypomyelination/vanishing white matter), full gene sequenceENG (endoglin) (eg, hereditary hemorrhagic telangiectasia, type 1), full gene sequenceEYA1 (eyes absent homolog 1 [Drosophila]) (eg, branchio-oto-renal [BOR] spectrum disorders), full gene sequenceF8 (coagulation factor VIII) (eg, hemophilia A), duplication/deletion analysisFAH (fumarylacetoacetate hydrolase [fumarylacetoacetase]) (eg, tyrosinemia, type 1), full gene sequenceFASTKD2

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory (continued)

81406

(FAST kinase domains 2) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequence FIG4 (FIG4 homolog, SAC1 lipid phosphatase domain containing [S. cerevisiae]) (eg, Charcot-Marie-Tooth disease), full gene sequence FTSJ1 (FtsJ RNA 2’-O-methyltransferase 1) (eg, X-linked intellectual disability 9), full gene sequence FUS (fused in sarcoma) (eg, amyotrophic lateral sclerosis), full gene sequence GAA (glucosidase, alpha; acid) (eg, glycogen storage disease type II [Pompe disease]),

full gene sequence GALC (galactosylceramidase) (eg, Krabbe disease), full gene sequence GALT (galactose-1-phosphate uridylyltransferase) (eg, galactosemia), full gene sequence GARS (glycyl-tRNA synthetase) (eg, Charcot-Marie-Tooth disease),

full gene sequence GCDH (glutaryl-CoA dehydrogenase) (eg, glutaricacidemia type 1), full gene sequence GCK (glucokinase [hexokinase 4]) (eg, maturity-onset diabetes of the young [MODY]), full gene sequence GLUD1 (glutamate dehydrogenase 1) (eg, familial hyperinsulinism), full gene sequence GNE (glucosamine [UDP-N-acetyl]-2-epimerase/N-acetylmannosamine kinase) (eg, inclusion body myopathy 2 [IBM2], Nonaka myopathy), full gene sequence GRN (granulin) (eg, frontotemporal dementia), full

gene sequence HADHA (hydroxyacyl-CoA dehydrogenase/3- ketoacyl-CoA thiolase/enoyl-CoA hydratase [trifunctional protein] alpha subunit) (eg, long chain acyl-coenzyme A dehydrogenase deficiency), full gene sequence HADHB (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/ enoyl-CoA hydratase [trifunctional protein], beta subunit) (eg, trifunctional protein deficiency), full gene sequence HEXA (hexosaminidase A, alpha polypeptide) (eg, Tay-Sachs disease), full gene sequence HLCS (HLCS holocarboxylase synthetase) (eg, holocarboxylase synthetase deficiency), full gene sequence HMBS (hydroxymethylbilane synthase) (eg, acute intermittent porphyria), full gene sequence HNF4A (hepatocyte nuclear factor 4, alpha) (eg, maturity-onset diabetes of the young [MODY]), full gene sequence IDUA (iduronidase, alpha-L-) (eg,

mucopolysaccharidosis type I), full gene sequence INF2 (inverted formin, FH2 and WH2 domain containing) (eg, focal segmental glomerulosclerosis), full gene sequence IVD (isovaleryl-CoA dehydrogenase) (eg, isovaleric acidemia), full gene sequence JAG1 (jagged 1) (eg, Alagille syndrome), duplication/deletion analysis JUP (junction plakoglobin) (eg, arrhythmogenic right ventricular dysplasia/cardiomyopathy 11), full gene sequence KCNH2 (potassium voltage-gated channel, subfamily H [eag- related], member 2) (eg, short QT syndrome, long QT syndrome), full gene sequence KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) (eg, short QT syndrome, long QT syndrome), full gene sequence KCNQ2 (potassium voltage- gated channel, KQT-like subfamily, member 2) (eg, epileptic encephalopathy), full gene sequence LDB3 (LIM domain binding 3) (eg, familial dilated cardiomyopathy, myofibrillar myopathy),

full gene sequence LDLR (low density lipoprotein receptor) (eg, familial hypercholesterolemia), full gene sequence LEPR (leptin receptor) (eg, obesity with hypogonadism), full gene sequence LHCGR (luteinizing hormone/choriogonadotropin receptor) (eg, precocious male puberty), full gene sequence LMNA (lamin A/C) (eg, Emery-Dreifuss muscular dystrophy [EDMD1, 2 and 3] limb- girdle muscular dystrophy [LGMD] type 1B, dilated cardiomyopathy [CMD1A], familial partial lipodystrophy [FPLD2]), full gene sequence LRP5 (low density lipoprotein receptor-related protein 5) (eg, osteopetrosis), full gene sequence MAP2K1 (mitogen- activated protein kinase 1) (eg, cardiofaciocutaneous syndrome), full gene sequence MAP2K2 (mitogen-activated protein kinase

2) (eg, cardiofaciocutaneous syndrome), full gene sequence MAPT (microtubule-associated protein tau) (eg, frontotemporal dementia), full gene sequence MCCC1 (methylcrotonoyl-CoA carboxylase 1 [alpha]) (eg, 3-methylcrotonyl-CoA carboxylase deficiency), full gene sequence MCCC2 (methylcrotonoyl-

CoA carboxylase 2 [beta]) (eg, 3-methylcrotonyl carboxylase deficiency), full gene sequence MFN2 (mitofusin 2) (eg, Charcot- Marie-Tooth disease), full gene sequence MTM1 (myotubularin 1) (eg, X-linked centronuclear myopathy), full gene sequence MUT (methylmalonyl CoA mutase) (eg, methylmalonic acidemia), full gene sequence MUTYH (mutY homolog [E. coli]) (eg, MYH- associated polyposis), full gene sequence NDUFS1 (NADH dehydrogenase [ubiquinone] Fe-S protein 1, 75kDa [NADH- coenzyme Q reductase]) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequence NF2 (neurofibromin

2 [merlin]) (eg, neurofibromatosis, type 2), full gene sequence NOTCH3 (notch 3) (eg, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL]),

(FAST kinase domains 2) (eg, mitochondrial respiratory chain complex IV deficiency), full gene sequenceFIG4 (FIG4 homolog, SAC1 lipid phosphatase domain containing [S. cerevisiae]) (eg, Charcot-Marie-Tooth disease), full gene sequenceFTSJ1 (FtsJ RNA methyltransferase homolog 1 [E. coli]) (eg, X-linked mental retardation 9), full gene sequenceFUS (fused in sarcoma)

(eg, amyotrophic lateral sclerosis), full gene sequenceGAA (glucosidase, alpha; acid) (eg, glycogen storage disease type II [Pompe disease]), full gene sequenceGALC (galactosylceramidase) (eg, Krabbe disease), full gene sequenceGALT (galactose-1- phosphate uridylyltransferase) (eg, galactosemia), full gene sequenceGARS (glycyl-tRNA synthetase) (eg, Charcot-Marie-Tooth disease), full gene sequenceGCDH (glutaryl-CoA dehydrogenase) (eg, glutaricacidemia type 1), full gene sequenceGCK (glucokinase [hexokinase 4]) (eg, maturity-onset diabetes of the young [MODY]), full gene sequenceGLUD1 (glutamate dehydrogenase 1) (eg, familial hyperinsulinism), full gene sequenceGNE (glucosamine [UDP-N-acetyl]-2-epimerase/N-acetylmannosamine kinase) (eg, inclusion body myopathy 2 [IBM2], Nonaka myopathy), full gene sequenceGRN (granulin) (eg, frontotemporal dementia), full

gene sequenceHADHA (hydroxyacyl-CoA dehydrogenase/3-

ketoacyl-CoA thiolase/enoyl-CoA hydratase [trifunctional protein] alpha subunit) (eg, long chain acyl-coenzyme A dehydrogenase deficiency), full gene sequenceHADHB (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/ enoyl-CoA hydratase [trifunctional protein], beta subunit) (eg, trifunctional protein deficiency), full gene sequenceHEXA (hexosaminidase A, alpha polypeptide) (eg, Tay-Sachs disease),

full gene sequenceHLCS (HLCS holocarboxylase synthetase) (eg, holocarboxylase synthetase deficiency), full gene sequenceHMBS (hydroxymethylbilane synthase) (eg, acute intermittent porphyria), full gene sequenceHNF4A (hepatocyte nuclear factor 4, alpha) (eg, maturity-onset diabetes of the young [MODY]), full gene sequenceIDUA (iduronidase, alpha-L-) (eg, mucopolysaccharidosis type I), full gene sequenceINF2 (inverted formin, FH2 and WH2 domain containing) (eg, focal segmental glomerulosclerosis),

full gene sequenceIVD (isovaleryl-CoA dehydrogenase) (eg, isovaleric acidemia), full gene sequenceJAG1 (jagged 1) (eg, Alagille syndrome), duplication/deletion analysisJUP (junction plakoglobin) (eg, arrhythmogenic right ventricular dysplasia/cardiomyopathy

11), full gene sequenceKCNH2 (potassium voltage-gated channel, subfamily H [eag-related], member 2) (eg, short QT syndrome, long QT syndrome), full gene sequenceKCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) (eg, short QT syndrome, long QT syndrome), full gene sequenceKCNQ2 (potassium

voltage-gated channel, KQT-like subfamily, member 2) (eg, epileptic encephalopathy), full gene sequenceLDB3 (LIM domain binding

3) (eg, familial dilated cardiomyopathy, myofibrillar myopathy), full gene sequenceLDLR (low density lipoprotein receptor) (eg, familial hypercholesterolemia), full gene sequenceLEPR (leptin receptor) (eg, obesity with hypogonadism), full gene sequenceLHCGR (luteinizing hormone/choriogonadotropin

receptor) (eg, precocious male puberty), full gene sequenceLMNA (lamin A/C) (eg, Emery-Dreifuss muscular dystrophy [EDMD1, 2

and 3] limb-girdle muscular dystrophy [LGMD] type 1B, dilated cardiomyopathy [CMD1A], familial partial lipodystrophy [FPLD2]), full gene sequenceLRP5 (low density lipoprotein receptor-related

protein 5) (eg, osteopetrosis), full gene sequenceMAP2K1 (mitogen- activated protein kinase 1) (eg, cardiofaciocutaneous syndrome), full gene sequenceMAP2K2 (mitogen-activated protein kinase 2) (eg, cardiofaciocutaneous syndrome), full gene sequenceMAPT (microtubule-associated protein tau) (eg, frontotemporal dementia), full gene sequenceMCCC1 (methylcrotonoyl-CoA carboxylase 1 [alpha]) (eg, 3-methylcrotonyl-CoA carboxylase deficiency), full gene sequenceMCCC2 (methylcrotonoyl-CoA carboxylase 2 [beta]) (eg, 3-methylcrotonyl carboxylase deficiency), full gene sequenceMFN2 (mitofusin 2) (eg, Charcot-Marie-Tooth disease), full gene sequenceMTM1 (myotubularin 1) (eg, X-linked centronuclear myopathy), full gene sequenceMUT (methylmalonyl CoA mutase) (eg, methylmalonic acidemia), full gene sequenceMUTYH

(mutY homolog [E. coli]) (eg, MYH-associated polyposis), full

gene sequenceNDUFS1 (NADH dehydrogenase [ubiquinone] Fe-S protein 1, 75kDa [NADH-coenzyme Q reductase]) (eg, Leigh syndrome, mitochondrial complex I deficiency), full gene sequenceNF2 (neurofibromin 2 [merlin]) (eg, neurofibromatosis, type 2), full gene sequenceNOTCH3 (notch 3) (eg, cerebral autosomal dominant arteriopathy with subcortical infarcts and

leukoencephalopathy [CADASIL]), targeted sequence analysis (eg, exons 1-23)NPC1 (Niemann-Pick disease, type C1) (eg, Niemann-Pick disease), full gene sequenceNPHP1 (nephronophthisis 1 [juvenile]) (eg, Joubert syndrome), full gene sequenceNSD1

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory (continued)

81406

targeted sequence analysis (eg, exons 1-23) NPC1 (Niemann-Pick disease, type C1) (eg, Niemann-Pick disease), full gene sequence NPHP1

(nephronophthisis 1 [juvenile]) (eg, Joubert syndrome), full gene sequence NSD1 (nuclear receptor binding SET domain protein 1) (eg, Sotos syndrome), full gene sequence OPA1 (optic atrophy 1) (eg, optic atrophy), duplication/ deletion analysis OPTN (optineurin) (eg, amyotrophic lateral sclerosis), full gene sequence PAFAH1B1 (platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 [45kDa]) (eg, lissencephaly, Miller-Dieker syndrome),

full gene sequence PAH (phenylalanine hydroxylase) (eg, phenylketonuria), full gene sequence PARK2 (Parkinson protein 2, E3 ubiquitin protein

ligase [parkin]) (eg, Parkinson disease), full gene sequence PAX2 (paired box 2) (eg, renal coloboma syndrome), full gene sequence PC (pyruvate carboxylase) (eg, pyruvate carboxylase deficiency), full gene sequence PCCA (propionyl CoA carboxylase, alpha polypeptide) (eg, propionic acidemia, type 1), full gene sequence PCCB (propionyl CoA carboxylase, beta polypeptide) (eg, propionic acidemia), full gene sequence PCDH15 (protocadherin-related 15) (eg, Usher syndrome type 1F), duplication/ deletion analysis PCSK9 (proprotein convertase subtilisin/kexin type 9) (eg, familial hypercholesterolemia), full gene sequence PDHA1 (pyruvate

dehydrogenase [lipoamide] alpha 1) (eg, lactic acidosis), full gene sequence PDHX (pyruvate dehydrogenase complex, component X) (eg, lactic acidosis), full gene sequence PHEX (phosphate-regulating endopeptidase homolog,

X-linked) (eg, hypophosphatemic rickets), full gene sequence PKD2 (polycystic kidney disease 2 [autosomal dominant]) (eg, polycystic kidney disease), full gene sequence PKP2 (plakophilin 2) (eg, arrhythmogenic right ventricular dysplasia/cardiomyopathy 9), full gene sequence PNKD (paroxysmal nonkinesigenic dyskinesia) (eg, paroxysmal nonkinesigenic

dyskinesia), full gene sequence POLG (polymerase [DNA directed], gamma) (eg, Alpers-Huttenlocher syndrome, autosomal dominant progressive external ophthalmoplegia), full gene sequence POMGNT1 (protein O-linked mannose beta1,2-N acetylglucosaminyltransferase) (eg, muscle-eye-brain disease, Walker-Warburg syndrome), full gene sequence POMT1 (protein- O-mannosyltransferase 1) (eg, limb-girdle muscular dystrophy [LGMD] type 2K, Walker-Warburg syndrome), full gene sequence POMT2 (protein-O-

mannosyltransferase 2) (eg, limb-girdle muscular dystrophy [LGMD] type 2N, Walker-Warburg syndrome), full gene sequence PPOX (protoporphyrinogen oxidase) (eg, variegate porphyria), full gene sequence PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit) (eg, familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome, lethal congenital glycogen storage disease of heart), full gene sequence PRKCG (protein kinase C, gamma) (eg, spinocerebellar ataxia), full gene sequence PSEN2 (presenilin 2 [Alzheimer disease 4]) (eg, Alzheimer disease), full gene sequence PTPN11 (protein tyrosine phosphatase, non-receptor type

11) (eg, Noonan syndrome, LEOPARD syndrome), full gene sequence PYGM (phosphorylase, glycogen, muscle) (eg, glycogen storage disease type V, McArdle disease), full gene sequence RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1) (eg, LEOPARD syndrome), full gene sequence RET (ret proto-oncogene) (eg, Hirschsprung disease), full gene sequence RPE65 (retinal pigment epithelium-specific protein 65kDa) (eg, retinitis pigmentosa, Leber congenital amaurosis), full gene sequence RYR1 (ryanodine receptor 1, skeletal) (eg, malignant hyperthermia), targeted sequence analysis of exons with functionally-confirmed mutations SCN4A (sodium channel, voltage- gated, type IV, alpha subunit) (eg, hyperkalemic periodic paralysis), full

gene sequence SCNN1A (sodium channel, nonvoltage-gated 1 alpha) (eg, pseudohypoaldosteronism), full gene sequence SCNN1B (sodium channel, nonvoltage-gated 1, beta) (eg, Liddle syndrome, pseudohypoaldosteronism), full gene sequence SCNN1G (sodium channel, nonvoltage-gated 1, gamma) (eg, Liddle syndrome, pseudohypoaldosteronism), full gene sequence SDHA (succinate dehydrogenase complex, subunit A, flavoprotein [Fp]) (eg, Leigh syndrome, mitochondrial complex II deficiency), full gene sequence SETX (senataxin) (eg, ataxia), full gene sequence SGCE (sarcoglycan, epsilon)

(eg, myoclonic dystonia), full gene sequence SH3TC2 (SH3 domain and tetratricopeptide repeats 2) (eg, Charcot-Marie-Tooth disease), full gene sequence SLC9A6 (solute carrier family 9 [sodium/hydrogen exchanger], member 6) (eg, Christianson syndrome), full gene sequence SLC26A4 (solute carrier family 26, member 4) (eg, Pendred syndrome), full gene sequence SLC37A4 (solute carrier family 37 [glucose-6-phosphate transporter], member 4) (eg, glycogen storage disease type Ib), full gene sequence SMAD4

(SMAD family member 4) (eg, hemorrhagic telangiectasia syndrome, juvenile polyposis), full gene sequence SOS1 (son of sevenless homolog 1) (eg, Noonan syndrome, gingival fibromatosis), full gene sequence SPAST (spastin) (eg, spastic paraplegia), full gene sequence SPG7 (spastic paraplegia 7 [pure and complicated autosomal recessive]) (eg, spastic paraplegia), full gene sequence STXBP1 (syntaxin-binding protein 1) (eg, epileptic encephalopathy), full gene sequence TAZ (tafazzin) (eg, methylglutaconic aciduria type 2, Barth syndrome), full gene sequence TCF4 (transcription factor 4) (eg, Pitt-Hopkins syndrome), full gene sequence TH (tyrosine hydroxylase) (eg, Segawa syndrome), full gene sequence TMEM43 (transmembrane protein 43) (eg, arrhythmogenic right ventricular cardiomyopathy), full gene sequence TNNT2 (troponin T, type 2 [cardiac]) (eg, familial hypertrophic cardiomyopathy),

full gene sequence TRPC6 (transient receptor potential cation channel, subfamily C, member 6) (eg, focal segmental glomerulosclerosis), full gene sequence TSC1 (tuberous sclerosis 1) (eg, tuberous sclerosis), full gene sequence TSC2 (tuberous sclerosis 2) (eg, tuberous sclerosis), duplication/ deletion analysis UBE3A (ubiquitin protein ligase E3A) (eg, Angelman syndrome), full gene sequence UMOD (uromodulin) (eg, glomerulocystic kidney disease with hyperuricemia and isosthenuria), full gene sequence VWF (von Willebrand factor) (von Willebrand disease type 2A), extended targeted sequence analysis (eg, exons 11-16, 24-26, 51, 52) WAS (Wiskott- Aldrich syndrome [eczema-thrombocytopenia]) (eg, Wiskott-Aldrich syndrome), full gene sequence

(nuclear receptor binding SET domain protein 1) (eg, Sotos syndrome), full gene sequenceOPA1 (optic atrophy 1) (eg, optic atrophy), duplication/ deletion analysisOPTN (optineurin) (eg, amyotrophic lateral sclerosis), full gene sequencePAFAH1B1 (platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 [45kDa]) (eg, lissencephaly, Miller-Dieker syndrome),

full gene sequencePAH (phenylalanine hydroxylase) (eg, phenylketonuria), full gene sequencePARK2 (Parkinson protein 2, E3 ubiquitin protein ligase [parkin]) (eg, Parkinson disease), full gene sequencePAX2 (paired box 2) (eg, renal coloboma syndrome), full gene sequencePC (pyruvate carboxylase) (eg, pyruvate carboxylase deficiency), full gene sequencePCCA (propionyl CoA carboxylase, alpha polypeptide) (eg, propionic acidemia, type 1), full gene sequencePCCB (propionyl CoA carboxylase, beta polypeptide)

(eg, propionic acidemia), full gene sequencePCDH15 (protocadherin- related 15) (eg, Usher syndrome type 1F), duplication/deletion analysisPCSK9 (proprotein convertase subtilisin/kexin type 9) (eg, familial hypercholesterolemia), full gene sequencePDHA1 (pyruvate dehydrogenase [lipoamide] alpha 1) (eg, lactic acidosis), full gene sequencePDHX

(pyruvate dehydrogenase complex, component X) (eg, lactic acidosis), full gene sequencePHEX (phosphate-regulating endopeptidase homolog,

X-linked) (eg, hypophosphatemic rickets), full gene sequencePKD2 (polycystic kidney disease 2 [autosomal dominant]) (eg, polycystic kidney disease), full gene sequencePKP2 (plakophilin 2) (eg, arrhythmogenic right ventricular dysplasia/cardiomyopathy 9), full gene sequencePNKD (paroxysmal nonkinesigenic dyskinesia) (eg, paroxysmal nonkinesigenic

dyskinesia), full gene sequencePOLG (polymerase [DNA directed], gamma) (eg, Alpers-Huttenlocher syndrome, autosomal dominant progressive external ophthalmoplegia), full gene sequencePOMGNT1 (protein O-linked mannose beta1,2-N acetylglucosaminyltransferase) (eg, muscle-eye-brain disease, Walker-Warburg syndrome), full gene sequencePOMT1 (protein- O-mannosyltransferase 1) (eg, limb-girdle muscular dystrophy [LGMD] type 2K, Walker-Warburg syndrome), full gene sequencePOMT2 (protein-O-

mannosyltransferase 2) (eg, limb-girdle muscular dystrophy [LGMD] type 2N, Walker-Warburg syndrome), full gene sequencePPOX (protoporphyrinogen oxidase) (eg, variegate porphyria), full gene sequencePRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit) (eg, familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome, lethal congenital glycogen storage disease of heart), full gene sequencePRKCG (protein kinase C, gamma) (eg, spinocerebellar ataxia), full gene sequencePSEN2 (presenilin 2 [Alzheimer disease 4]) (eg, Alzheimer disease), full gene sequencePTPN11 (protein tyrosine phosphatase,

non-receptor type 11) (eg, Noonan syndrome, LEOPARD syndrome), full gene sequencePYGM (phosphorylase, glycogen, muscle) (eg, glycogen storage disease type V, McArdle disease), full gene sequenceRAF1 (v-raf-1 murine leukemia viral oncogene homolog 1) (eg, LEOPARD syndrome),

full gene sequenceRET (ret proto-oncogene) (eg, Hirschsprung disease), full gene sequenceRPE65 (retinal pigment epithelium-specific protein 65kDa) (eg, retinitis pigmentosa, Leber congenital amaurosis), full gene sequenceRYR1 (ryanodine receptor 1, skeletal) (eg, malignant hyperthermia), targeted sequence analysis of exons with functionally-confirmed mutationsSCN4A (sodium channel, voltage-gated, type IV, alpha subunit) (eg, hyperkalemic periodic paralysis), full gene sequenceSCNN1A (sodium channel, nonvoltage-gated 1 alpha) (eg, pseudohypoaldosteronism), full gene sequenceSCNN1B (sodium channel, nonvoltage-gated 1, beta) (eg, Liddle syndrome, pseudohypoaldosteronism), full gene sequenceSCNN1G (sodium channel, nonvoltage-gated 1, gamma) (eg, Liddle syndrome, pseudohypoaldosteronism), full gene sequenceSDHA (succinate dehydrogenase complex, subunit A, flavoprotein [Fp]) (eg, Leigh syndrome, mitochondrial complex II deficiency), full gene sequenceSETX (senataxin) (eg, ataxia), full gene sequenceSGCE (sarcoglycan, epsilon) (eg, myoclonic dystonia), full gene sequenceSH3TC2 (SH3 domain and tetratricopeptide repeats 2) (eg, Charcot-Marie-Tooth disease), full gene sequenceSLC9A6 (solute carrier family 9 [sodium/hydrogen exchanger], member 6) (eg, Christianson syndrome), full gene sequenceSLC26A4 (solute carrier family 26, member 4) (eg, Pendred syndrome), full gene sequenceSLC37A4 (solute carrier family 37 [glucose-6-phosphate transporter], member 4) (eg,

glycogen storage disease type Ib), full gene sequenceSMAD4 (SMAD family member 4) (eg, hemorrhagic telangiectasia syndrome, juvenile polyposis), full gene sequenceSOS1 (son of sevenless homolog 1) (eg, Noonan syndrome, gingival fibromatosis), full gene sequenceSPAST (spastin) (eg, spastic paraplegia), full gene sequenceSPG7 (spastic paraplegia 7 [pure and complicated autosomal recessive]) (eg, spastic paraplegia), full gene

sequenceSTXBP1 (syntaxin-binding protein 1) (eg, epileptic encephalopathy), full gene sequenceTAZ (tafazzin) (eg, methylglutaconic aciduria type 2, Barth syndrome), full gene sequenceTCF4 (transcription factor 4) (eg, Pitt-Hopkins syndrome), full gene sequenceTH (tyrosine hydroxylase) (eg, Segawa syndrome), full gene sequenceTMEM43 (transmembrane protein 43) (eg, arrhythmogenic right ventricular cardiomyopathy), full gene sequenceTNNT2 (troponin T, type 2 [cardiac]) (eg, familial hypertrophic cardiomyopathy),

full gene sequenceTRPC6 (transient receptor potential cation channel, subfamily C, member 6) (eg, focal segmental glomerulosclerosis), full gene sequenceTSC1 (tuberous sclerosis 1) (eg, tuberous sclerosis), full gene sequenceTSC2 (tuberous sclerosis 2) (eg, tuberous sclerosis), duplication/ deletion analysisUBE3A (ubiquitin protein ligase E3A) (eg, Angelman syndrome), full gene sequenceUMOD (uromodulin) (eg, glomerulocystic kidney disease with hyperuricemia and isosthenuria), full gene sequenceVWF (von Willebrand factor) (von Willebrand disease type 2A), extended targeted sequence analysis (eg, exons 11-16, 24-26, 51, 52)WAS (Wiskott-Aldrich syndrome [eczema-thrombocytopenia]) (eg, Wiskott-Aldrich syndrome), full gene sequence

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory

81407

Molecular pathology procedure, Level 8 (eg, analysis of 26- 50 exons by DNA sequence analysis, mutation scanning or

duplication/deletion variants of >50 exons, sequence analysis of multiple genes on one platform) ABCC8 (ATP-binding cassette, sub-family C [CFTR/MRP], member 8) (eg, familial hyperinsulinism), full gene sequence AGL (amylo-alpha-1, 6-glucosidase, 4-alpha- glucanotransferase) (eg, glycogen storage disease type III), full gene sequence AHI1 (Abelson helper integration site 1) (eg, Joubert syndrome), full gene sequence APOB (apolipoprotein

B) (eg, familial hypercholesterolemia type B) full gene sequence ASPM (asp [abnormal spindle] homolog, microcephaly associated [Drosophila]) (eg, primary microcephaly), full gene sequence CHD7 (chromodomain helicase DNA binding protein 7) (eg, CHARGE syndrome), full gene sequence COL4A4 (collagen, type IV, alpha 4) (eg, Alport syndrome), full gene sequence COL4A5 (collagen, type IV, alpha 5) (eg, Alport syndrome), duplication/ deletion analysis COL6A1 (collagen, type VI, alpha 1) (eg, collagen type VI-related disorders), full gene sequence COL6A2 (collagen, type VI, alpha 2) (eg, collagen type VI-related disorders), full gene sequence COL6A3 (collagen, type VI, alpha 3) (eg, collagen type VI-related disorders), full gene sequence CREBBP (CREB binding protein) (eg, Rubinstein-Taybi syndrome), full gene sequence F8 (coagulation factor VIII) (eg, hemophilia A), full gene sequence JAG1 (jagged 1) (eg, Alagille syndrome), full gene sequence KDM5C (lysine demethylase 5C) (eg, X-linked intellectual disability), full gene sequence KIAA0196 (KIAA0196) (eg, spastic paraplegia), full gene sequence L1CAM (L1 cell adhesion molecule) (eg, MASA syndrome, X-linked hydrocephaly), full gene sequence LAMB2 (laminin, beta 2 [laminin S]) (eg, Pierson syndrome), full gene sequence MYBPC3 (myosin binding protein C, cardiac) (eg, familial hypertrophic cardiomyopathy), full gene sequence MYH6 (myosin, heavy chain 6, cardiac muscle, alpha) (eg, familial dilated cardiomyopathy), full gene sequence MYH7 (myosin, heavy chain 7, cardiac muscle, beta) (eg, familial hypertrophic cardiomyopathy, Liang distal myopathy), full gene sequence MYO7A (myosin

VIIA) (eg, Usher syndrome, type 1), full gene sequence NOTCH1 (notch 1) (eg, aortic valve disease), full gene sequence NPHS1 (nephrosis 1, congenital, Finnish type [nephrin]) (eg, congenital Finnish nephrosis), full gene sequence OPA1 (optic atrophy 1) (eg, optic atrophy), full gene sequence PCDH15 (protocadherin-

related 15) (eg, Usher syndrome, type 1), full gene sequence PKD1 (polycystic kidney disease 1 [autosomal dominant]) (eg, polycystic kidney disease), full gene sequence PLCE1 (phospholipase C, epsilon 1) (eg, nephrotic syndrome type 3), full gene sequence SCN1A (sodium channel, voltage-gated, type 1, alpha subunit) (eg, generalized epilepsy with febrile seizures), full gene sequence SCN5A (sodium channel, voltage-gated, type V, alpha subunit) (eg, familial dilated cardiomyopathy), full gene sequence SLC12A1 (solute carrier family 12 [sodium/potassium/chloride transporters], member 1) (eg, Bartter syndrome), full gene sequence SLC12A3 (solute carrier family 12 [sodium/chloride transporters], member

3) (eg, Gitelman syndrome), full gene sequence SPG11 (spastic paraplegia 11 [autosomal recessive]) (eg, spastic paraplegia), full gene sequence SPTBN2

(spectrin, beta, non-erythrocytic 2) (eg, spinocerebellar ataxia), full gene sequence TMEM67 (transmembrane protein 67) (eg, Joubert syndrome), full gene sequence TSC2

(tuberous sclerosis 2) (eg, tuberous sclerosis), full gene sequence USH1C (Usher syndrome 1C [autosomal recessive, severe]) (eg, Usher syndrome, type 1), full gene sequence VPS13B (vacuolar protein sorting 13 homolog B [yeast]) (eg, Cohen syndrome), duplication/deletion analysis WDR62 (WD repeat domain 62) (eg, primary autosomal recessive microcephaly), full gene sequence

Molecular pathology procedure, Level 8 (eg, analysis of 26- 50 exons by DNA sequence analysis, mutation scanning or

4-alpha-glucanotransferase) (eg, glycogen storage disease type III), full gene sequenceAHI1 (Abelson helper integration site 1) (eg, Joubert syndrome), full gene sequenceAPOB (apolipoprotein B) (eg, familial hypercholesterolemia type B) full gene sequenceASPM (asp [abnormal spindle] homolog,

microcephaly associated [Drosophila]) (eg, primary microcephaly), full gene sequenceCHD7 (chromodomain helicase DNA binding protein 7) (eg, CHARGE syndrome), full gene sequenceCOL4A4 (collagen, type IV, alpha 4) (eg, Alport syndrome), full gene sequenceCOL4A5 (collagen, type IV, alpha 5) (eg, Alport syndrome), duplication/deletion analysisCOL6A1 (collagen, type VI, alpha 1) (eg, collagen type VI-related disorders), full gene sequenceCOL6A2 (collagen, type VI, alpha 2) (eg, collagen type VI-related disorders), full gene sequenceCOL6A3 (collagen, type VI, alpha 3) (eg, collagen type VI-related disorders), full gene sequenceCREBBP (CREB binding protein) (eg, Rubinstein-Taybi syndrome), full gene sequenceF8 (coagulation factor VIII) (eg, hemophilia A), full gene sequenceJAG1 (jagged 1) (eg, Alagille syndrome), full gene sequenceKDM5C (lysine [K]-specific demethylase 5C) (eg, X-linked mental retardation), full gene sequenceKIAA0196 (KIAA0196) (eg, spastic paraplegia), full

gene sequenceL1CAM (L1 cell adhesion molecule) (eg, MASA syndrome, X-linked hydrocephaly), full gene sequenceLAMB2 (laminin, beta 2 [laminin S]) (eg, Pierson syndrome), full gene sequenceMYBPC3 (myosin binding protein C, cardiac) (eg, familial hypertrophic cardiomyopathy), full gene sequenceMYH6 (myosin, heavy chain 6, cardiac muscle, alpha) (eg, familial dilated cardiomyopathy), full gene sequenceMYH7 (myosin, heavy chain 7, cardiac muscle, beta) (eg, familial hypertrophic cardiomyopathy, Liang distal myopathy), full gene sequenceMYO7A (myosin

VIIA) (eg, Usher syndrome, type 1), full gene sequenceNOTCH1 (notch 1) (eg, aortic valve disease), full gene sequenceNPHS1 (nephrosis 1, congenital, Finnish type [nephrin]) (eg, congenital Finnish nephrosis), full gene sequenceOPA1 (optic atrophy 1) (eg, optic atrophy), full gene sequencePCDH15 (protocadherin-

related 15) (eg, Usher syndrome, type 1), full gene sequencePKD1 (polycystic kidney disease 1 [autosomal dominant]) (eg, polycystic kidney disease), full gene sequencePLCE1 (phospholipase

C, epsilon 1) (eg, nephrotic syndrome type 3), full gene sequenceSCN1A (sodium channel, voltage-gated, type 1, alpha subunit) (eg, generalized epilepsy with febrile seizures), full gene sequenceSCN5A (sodium channel, voltage-gated, type V, alpha subunit) (eg, familial dilated cardiomyopathy), full gene sequenceSLC12A1 (solute carrier family 12 [sodium/potassium/ chloride transporters], member 1) (eg, Bartter syndrome), full

gene sequenceSLC12A3 (solute carrier family 12 [sodium/chloride transporters], member 3) (eg, Gitelman syndrome), full gene sequenceSPG11 (spastic paraplegia 11 [autosomal recessive])

(eg, spastic paraplegia), full gene sequenceSPTBN2 (spectrin, beta, non-erythrocytic 2) (eg, spinocerebellar ataxia), full gene sequenceTMEM67 (transmembrane protein 67) (eg, Joubert syndrome), full gene sequenceTSC2

(tuberous sclerosis 2) (eg, tuberous sclerosis), full gene sequenceUSH1C (Usher syndrome 1C [autosomal recessive, severe]) (eg, Usher syndrome, type 1), full gene sequenceVPS13B (vacuolar protein sorting 13 homolog B [yeast]) (eg, Cohen syndrome), duplication/deletion analysisWDR62 (WD repeat domain 62) (eg, primary autosomal recessive microcephaly), full gene sequence

Pathology and Laboratory

81445

Solid organ neoplasm, genomic sequence analysis panel, 5-50 genes, interrogation for sequence variants and copy number variants or rearrangements, if performed; DNA analysis or combined DNA and RNA analysis

Targeted genomic sequence analysis panel, solid organ neoplasm, 5-50 genes (eg, ALK, BRAF, CDKN2A, EGFR, ERBB2, KIT, KRAS, MET, NRAS, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN,

RET), interrogation for sequence variants and copy number variants or rearrangements, if performed; DNA analysis or combined DNA and RNA analysis

Pathology and Laboratory

81449

Solid organ neoplasm, genomic sequence analysis panel, 5-50 genes, interrogation for sequence variants and copy number variants or rearrangements, if performed; RNA analysis

Targeted genomic sequence analysis panel, solid organ neoplasm, 5-50 genes (eg, ALK, BRAF, CDKN2A, EGFR, ERBB2, KIT, KRAS, MET,

NRAS, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET), interrogation for

sequence variants and copy number variants or rearrangements, if performed; RNA analysis

Speciality

CPT

Code

2024 Description

2023 Description

Pathology and Laboratory

81450

Hematolymphoid neoplasm or disorder, genomic sequence analysis panel, 5-50 genes, interrogation for sequence variants, and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; DNA analysis or combined DNA and RNA analysis

Targeted genomic sequence analysis panel, hematolymphoid neoplasm or disorder, 5-50 genes (eg, BRAF, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MLL, NOTCH1, NPM1,

NRAS), interrogation for sequence variants, and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; DNA analysis or combined DNA and RNA analysis

Pathology and Laboratory

81451

Targeted genomic sequence analysis panel, hematolymphoid neoplasm or disorder, 5-50 genes (eg, BRAF, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MLL, NOTCH1, NPM1,

NRAS), interrogation for sequence variants, and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; RNA analysis

Pathology and Laboratory

81455

Solid organ or hematolymphoid neoplasm or disorder, 51 or greater genes, genomic sequence analysis panel, interrogation for sequence variants and copy number

variants or rearrangements, or isoform expression or mRNA expression levels, if performed; DNA analysis or combined DNA and RNA analysis

Targeted genomic sequence analysis panel, solid organ or hematolymphoid neoplasm or disorder, 51 or greater

genes (eg, ALK, BRAF, CDKN2A, CEBPA, DNMT3A, EGFR, ERBB2, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MET, MLL, NOTCH1, NPM1, NRAS, PDGFRA, PDGFRB, PGR, PIK3CA,

PTEN, RET), interrogation for sequence variants and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; DNA analysis or combined DNA and RNA analysis

Pathology and Laboratory

81456

Solid organ or hematolymphoid neoplasm or disorder, 51 or greater genes, genomic sequence analysis panel,

interrogation for sequence variants and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; RNA analysis

Targeted genomic sequence analysis panel, solid organ or hematolymphoid neoplasm or disorder, 51 or greater genes (eg, ALK, BRAF, CDKN2A, CEBPA, DNMT3A, EGFR, ERBB2, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MET, MLL, NOTCH1, NPM1, NRAS, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET),

interrogation for sequence variants and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; RNA analysis

Pathology and Laboratory

87467

Infectious agent antigen detection by immunoassay technique (eg, enzyme immunoassay [EIA], enzyme-linked

immunosorbent assay [ELISA], fluorescence immunoassay [FIA], immunochemiluminometric assay [IMCA]),

qualitative or semiquantitative; hepatitis B surface antigen (HBsAg), quantitative

Hepatitis B surface antigen (HBsAg), quantitative

Medicine Services and Procedures

Medicine Services and Procedures	91304	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, recombinant spike protein nanoparticle, saponin-based adjuvant, 5 mcg/0.5 mL dosage, for intramuscular use	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, recombinant spike protein nanoparticle, saponin-based adjuvant, 5 mcg/0.5 mL dosage, for intramuscular use
Medicine Services and Procedures	96446	Chemotherapy administration into the peritoneal cavity via implanted port or catheter	Chemotherapy administration into the peritoneal cavity via indwelling port or catheter
Medicine Services and Procedures	96920	Excimer laser treatment for psoriasis; total area less than 250 sq cm	Laser treatment for inflammatory skin disease (psoriasis); total area less than 250 sq cm
Medicine Services and Procedures	96921	Excimer laser treatment for psoriasis; 250 sq cm to 500 sq cm	Laser treatment for inflammatory skin disease (psoriasis); 250 sq cm to 500 sq cm
Medicine Services and Procedures	96922	Excimer laser treatment for psoriasis; over 500 sq cm	Laser treatment for inflammatory skin disease (psoriasis); over 500 sq cm

Evaluation and Management

99202

Office or other outpatient visit for the evaluation and management of a new patient, which requires a medically appropriate history and/or examination and straightforward medical decision making. When using total time on the date of the encounter for code selection, 15 minutes must be met or exceeded.

Office or other outpatient visit for the evaluation and management of a new patient, which requires a medically appropriate history and/or examination and straightforward medical decision making. When using time for code selection, 15-29 minutes of total time is spent on the date of the encounter.

Evaluation and Management

99203

Office or other outpatient visit for the evaluation and management of a new patient, which requires a medically appropriate history and/or examination and low level of medical decision making.

When using total time on the date of the encounter for code selection, 30 minutes must be met or exceeded.

Office or other outpatient visit for the evaluation and management of a new patient, which requires a medically appropriate history and/or examination and low level of medical decision making. When using time for code selection, 30-44 minutes of total time is spent on the date of the encounter.

Evaluation and Management

99204

Office or other outpatient visit for the evaluation and management of a new patient, which requires a medically appropriate history and/or examination and moderate level of medical decision making. When using total time on the date of the encounter for code selection, 45 minutes must be met or exceeded.

Office or other outpatient visit for the evaluation and management of a new patient, which requires a medically appropriate history and/or examination and moderate level of medical decision making. When using time for code selection, 45-59 minutes of total time is spent on the date of the encounter.

Speciality

CPT

Code

2024 Description

2023 Description

Evaluation and Management

99205

Office or other outpatient visit for the evaluation and management of a new patient, which requires a medically appropriate history and/or examination and high level of medical decision making.

When using total time on the date of the encounter for code selection, 60 minutes must be met or exceeded.

Office or other outpatient visit for the evaluation and management of a new patient, which requires a medically appropriate history and/or examination and high level of medical decision making. When using time for code selection, 60-74 minutes of total time is spent on the date of the encounter.

Evaluation and Management

99212

Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and straightforward medical decision making. When using total time on the date of the encounter for code selection, 10 minutes must be met or exceeded.

Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and

straightforward medical decision making. When using time for code selection, 10-19 minutes of total time is spent on the date of the encounter.

Evaluation and Management

99213

Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and low level of medical decision making. When using total time on the date of the encounter for code selection, 20 minutes must be met or exceeded.

Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and low level of medical decision making. When using time for code selection, 20-29 minutes of total time is spent on the date of the encounter.

Evaluation and Management

99214

Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and moderate level of medical decision making. When using total time on the date of the encounter for code selection, 30 minutes must be met or exceeded.

Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and moderate level of medical decision making. When using time for code selection, 30-39 minutes of total time is spent on the date of the encounter.

Evaluation and Management

99215

Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and high level of medical decision making. When using total time on the date of the encounter for code selection, 40 minutes must be met or exceeded.

Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and high level of medical decision making. When using time for code selection, 40-54 minutes of total time is spent on the date of the encounter.

Evaluation and Management

99306

Initial nursing facility care, per day, for the evaluation and management of a patient, which requires a medically appropriate history and/or examination and high level of medical decision making. When using total time on the date of the encounter for code selection, 50 minutes must be met or exceeded.

Evaluation and Management

99308

Subsequent nursing facility care, per day, for the evaluation and management of a patient, which requires a medically appropriate history and/or examination and low level of medical decision making. When using total time on the date of the encounter for code selection, 20 minutes must be met or exceeded.

Speciality

CPT Code

Description

Multianalyte Assay

0014M

Liver disease, analysis of 3 biomarkers (hyaluronic acid [HA], procollagen III amino terminal peptide [PIIINP], tissue inhibitor of metalloproteinase 1 [TIMP-1]), using immunoassays, utilizing serum, prognostic algorithm reported as a risk score and risk of liver fibrosis and liver-related clinical events within 5 years

Category III

Category III	0404T	Transcervical uterine fibroid(s) ablation with ultrasound guidance, radiofrequency
Category III	0424T	Insertion or replacement of neurostimulator system for treatment of central sleep apnea; complete system (transvenous placement of right or left stimulation lead, sensing lead, implantable pulse generator)
Category III	0425T	Insertion or replacement of neurostimulator system for treatment of central sleep apnea; sensing lead only
Category III	0426T	Insertion or replacement of neurostimulator system for treatment of central sleep apnea; stimulation lead only
Category III	0427T	Insertion or replacement of neurostimulator system for treatment of central sleep apnea; pulse generator only
Category III	0428T	Removal of neurostimulator system for treatment of central sleep apnea; pulse generator only
Category III	0429T	Removal of neurostimulator system for treatment of central sleep apnea; sensing lead only
Category III	0430T	Removal of neurostimulator system for treatment of central sleep apnea; stimulation lead only
Category III	0431T	Removal and replacement of neurostimulator system for treatment of central sleep apnea, pulse generator only
Category III	0432T	Repositioning of neurostimulator system for treatment of central sleep apnea; stimulation lead only
Category III	0433T	Repositioning of neurostimulator system for treatment of central sleep apnea; sensing lead only
Category III	0434T	Interrogation device evaluation implanted neurostimulator pulse generator system for central sleep apnea
Category III	0435T	Programming device evaluation of implanted neurostimulator pulse generator system for central sleep apnea; single session
Category III	0436T	Programming device evaluation of implanted neurostimulator pulse generator system for central sleep apnea; during sleep study
Category III	0465T	Suprachoroidal injection of a pharmacologic agent (does not include supply of medication)
Category III	0499T	Cystourethroscopy, with mechanical dilation and urethral therapeutic drug delivery for urethral stricture or stenosis, including fluoroscopy, when performed
Category III	0501T	Noninvasive estimated coronary fractional flow reserve (FFR) derived from coronary computed tomography angiography data using computation fluid dynamics physiologic simulation software analysis of functional data to assess the severity of coronary artery disease; data preparation and transmission, analysis of fluid dynamics and simulated maximal coronary hyperemia, generation of estimated FFR model, with anatomical data review in comparison with estimated FFR model to reconcile discordant data, interpretation and report
Category III	0502T	Noninvasive estimated coronary fractional flow reserve (FFR) derived from coronary computed tomography angiography data using computation fluid dynamics physiologic simulation software analysis of functional data to assess the severity of coronary artery disease; data preparation and transmission
Category III	0503T	Noninvasive estimated coronary fractional flow reserve (FFR) derived from coronary computed tomography angiography data using computation fluid dynamics physiologic simulation software analysis of functional data to assess the severity of coronary artery disease; analysis of fluid dynamics and simulated maximal coronary hyperemia, and generation of estimated FFR model
Category III	0504T	Noninvasive estimated coronary fractional flow reserve (FFR) derived from coronary computed tomography angiography data using computation fluid dynamics physiologic simulation software analysis of functional data to assess the severity of coronary artery disease; anatomical data review in comparison with estimated FFR model to reconcile discordant data, interpretation and report
Category III	0508T	Pulse-echo ultrasound bone density measurement resulting in indicator of axial bone mineral density, tibia
Category III	0533T	Continuous recording of movement disorder symptoms, including bradykinesia, dyskinesia, and tremor for 6 days up to 10 days; includes set-up, patient training, configuration of monitor, data upload, analysis and initial report configuration, download review, interpretation and report
Category III	0534T	Continuous recording of movement disorder symptoms, including bradykinesia, dyskinesia, and tremor for 6 days up to 10 days; set-up, patient training, configuration of monitor
Category III	0535T	Continuous recording of movement disorder symptoms, including bradykinesia, dyskinesia, and tremor for 6 days up to 10 days; data upload, analysis and initial report configuration
Category III	0536T	Continuous recording of movement disorder symptoms, including bradykinesia, dyskinesia, and tremor for 6 days up to 10 days; download review, interpretation and report
Category III	0641T	Noncontact near-infrared spectroscopy studies of flap or wound (eg, for measurement of deoxyhemoglobin, oxyhemoglobin, and ratio of tissue oxygenation [StO2]); image acquisition only, each flap or wound
Category III	0642T	Noncontact near-infrared spectroscopy studies of flap or wound (eg, for measurement of deoxyhemoglobin, oxyhemoglobin, and ratio of tissue oxygenation [StO2]); interpretation and report only, each flap or wound
Category III	0715T	Percutaneous transluminal coronary lithotripsy (List separately in addition to code for primary procedure)
Category III	0768T	Transcutaneous magnetic stimulation by focused low-frequency electromagnetic pulse, peripheral nerve, subsequent treatment, including noninvasive electroneurographic localization (nerve conduction localization), when performed; first nerve
Category III	0769T	Transcutaneous magnetic stimulation by focused low-frequency electromagnetic pulse, peripheral nerve, subsequent treatment, including noninvasive electroneurographic localization (nerve conduction localization), when performed; each additional nerve (List separately in addition to code for primary procedure)

Speciality	CPT Code	Description
Category III	0775T	Arthrodesis, sacroiliac joint, percutaneous, with image guidance, includes placement of intra-articular implant(s) (eg, bone allograft[s], synthetic device[s])
Category III	0809T	Arthrodesis, sacroiliac joint, percutaneous or minimally invasive (indirect visualization), with image guidance, placement of transfixing device(s) and intra-articular implant(s), including allograft or synthetic device(s)

Radiology

74710

Pelvimetry, with or without placental localization

2024 HCPCS Codes

Below are the 2024 HCPCS code updates. This list includes new HCPCS codes, revised codes and deleted codes.

Added HCPCS Codes for 2024

Speciality

HCPCS Code

Description

Medical And Surgical Supplies

Medical and Surgical Supplies	A4287	Disposable collection and storage bag for breast milk, any size, any type, each
Medical and Surgical Supplies	A4457	Enema tube, with or without adapter, any type, replacement only, each
Medical and Surgical Supplies	A4468	Exsufflation belt, includes all supplies and accessories
Medical and Surgical Supplies	A4540	Distal transcutaneous electrical nerve stimulator, stimulates peripheral nerves of the upper arm
Medical and Surgical Supplies	A4541	Monthly supplies for use of device coded at e0733
Medical and Surgical Supplies	A4542	Supplies and accessories for external upper limb tremor stimulator of the peripheral nerves of the wrist
Medical and Surgical Supplies	A6520	Gradient compression garment, glove, padded, for nighttime use, each
Medical and Surgical Supplies	A6521	Gradient compression garment, glove, padded, for nighttime use, custom, each
Medical and Surgical Supplies	A6522	Gradient compression garment, arm, padded, for nighttime use, each
Medical and Surgical Supplies	A6523	Gradient compression garment, arm, padded, for nighttime use, custom, each
Medical and Surgical Supplies	A6524	Gradient compression garment, lower leg and foot, padded, for nighttime use, each
Medical and Surgical Supplies	A6525	Gradient compression garment, lower leg and foot, padded, for nighttime use, custom, each
Medical and Surgical Supplies	A6526	Gradient compression garment, full leg and foot, padded, for nighttime use, each
Medical and Surgical Supplies	A6527	Gradient compression garment, full leg and foot, padded, for nighttime use, custom, each
Medical and Surgical Supplies	A6528	Gradient compression garment, bra, for nighttime use, each
Medical and Surgical Supplies	A6529	Gradient compression garment, bra, for nighttime use, custom, each
Medical and Surgical Supplies	A6552	Gradient compression stocking, below knee, 30-40 mmhg, each
Medical and Surgical Supplies	A6553	Gradient compression stocking, below knee, 30-40 mmhg, custom, each
Medical and Surgical Supplies	A6554	Gradient compression stocking, below knee, 40 mmhg or greater, each
Medical and Surgical Supplies	A6555	Gradient compression stocking, below knee, 40 mmhg or greater, custom, each
Medical and Surgical Supplies	A6556	Gradient compression stocking, thigh length, 18-30 mmhg, custom, each
Medical and Surgical Supplies	A6557	Gradient compression stocking, thigh length, 30-40 mmhg, custom, each
Medical and Surgical Supplies	A6558	Gradient compression stocking, thigh length, 40 mmhg or greater, custom, each
Medical and Surgical Supplies	A6559	Gradient compression stocking, full length/chap style, 18-30 mmhg, custom, each
Medical and Surgical Supplies	A6560	Gradient compression stocking, full length/chap style, 30-40 mmhg, custom, each
Medical and Surgical Supplies	A6561	Gradient compression stocking, full length/chap style, 40 mmhg or greater, custom, each
Medical and Surgical Supplies	A6562	Gradient compression stocking, waist length, 18-30 mmhg, custom, each
Medical and Surgical Supplies	A6563	Gradient compression stocking, waist length, 30-40 mmhg, custom, each
Medical and Surgical Supplies	A6564	Gradient compression stocking, waist length, 40 mmhg or greater, custom, each
Medical and Surgical Supplies	A6565	Gradient compression gauntlet, custom, each
Medical and Surgical Supplies	A6566	Gradient compression garment, neck/head, each
Medical and Surgical Supplies	A6567	Gradient compression garment, neck/head, custom, each
Medical and Surgical Supplies	A6568	Gradient compression garment, torso and shoulder, each
Medical and Surgical Supplies	A6569	Gradient compression garment, torso/shoulder, custom, each
Medical and Surgical Supplies	A6570	Gradient compression garment, genital region, each
Medical and Surgical Supplies	A6571	Gradient compression garment, genital region, custom, each
Medical and Surgical Supplies	A6572	Gradient compression garment, toe caps, each
Medical and Surgical Supplies	A6573	Gradient compression garment, toe caps, custom, each
Medical and Surgical Supplies	A6574	Gradient compression arm sleeve and glove combination, custom, each
Medical and Surgical Supplies	A6575	Gradient compression arm sleeve and glove combination, each
Medical and Surgical Supplies	A6576	Gradient compression arm sleeve, custom, medium weight, each
Medical and Surgical Supplies	A6577	Gradient compression arm sleeve, custom, heavy weight, each
Medical and Surgical Supplies	A6578	Gradient compression arm sleeve, each
Medical and Surgical Supplies	A6579	Gradient compression glove, custom, medium weight, each

Speciality	HCPCS Code	Description
Medical and Surgical Supplies	A6580	Gradient compression glove, custom, heavy weight, each
Medical and Surgical Supplies	A6581	Gradient compression glove, each
Medical and Surgical Supplies	A6582	Gradient compression gauntlet, each
Medical and Surgical Supplies	A6583	Gradient compression wrap with adjustable straps, below knee, 30-50 mmhg, each
Medical and Surgical Supplies	A6584	Gradient compression wrap with adjustable straps, not otherwise specified
Medical and Surgical Supplies	A6585	Gradient pressure wrap with adjustable straps, above knee, each
Medical and Surgical Supplies	A6586	Gradient pressure wrap with adjustable straps, full leg, each
Medical and Surgical Supplies	A6587	Gradient pressure wrap with adjustable straps, foot, each
Medical and Surgical Supplies	A6588	Gradient pressure wrap with adjustable straps, arm, each
Medical and Surgical Supplies	A6589	Gradient pressure wrap with adjustable straps, bra, each
Medical and Surgical Supplies	A6593	Accessory for gradient compression garment or wrap with adjustable straps, non-otherwise specified
Medical and Surgical Supplies	A6594	Gradient compression bandaging supply, bandage liner, lower extremity, any size or length, each
Medical and Surgical Supplies	A6595	Gradient compression bandaging supply, bandage liner, upper extremity, any size or length, each
Medical and Surgical Supplies	A6596	Gradient compression bandaging supply, conforming gauze, per linear yard, any width, each
Medical and Surgical Supplies	A6597	Gradient compression bandage roll, elastic long stretch, linear yard, any width, each
Medical and Surgical Supplies	A6598	Gradient compression bandage roll, elastic medium stretch, per linear yard, any width, each
Medical and Surgical Supplies	A6599	Gradient compression bandage roll, inelastic short stretch, per linear yard, any width, each
Medical and Surgical Supplies	A6600	Gradient compression bandaging supply, high density foam sheet, per 250 square centimeters, each
Medical and Surgical Supplies	A6601	Gradient compression bandaging supply, high density foam pad, any size or shape, each
Medical and Surgical Supplies	A6602	Gradient compression bandaging supply, high density foam roll for bandage, per linear yard, any width, each
Medical and Surgical Supplies	A6603	Gradient compression bandaging supply, low density channel foam sheet, per 250 square centimeters, each
Medical and Surgical Supplies	A6604	Gradient compression bandaging supply, low density flat foam sheet, per 250 square centimeters, each
Medical and Surgical Supplies	A6605	Gradient compression bandaging supply, padded foam, per linear yard, any width, each
Medical and Surgical Supplies	A6606	Gradient compression bandaging supply, padded textile, per linear yard, any width, each
Medical and Surgical Supplies	A6607	Gradient compression bandaging supply, tubular protective absorption layer, per linear yard, any width, each
Medical and Surgical Supplies	A6608	Gradient compression bandaging supply, tubular protective absorption padded layer, per linear yard, any width, each
Medical and Surgical Supplies	A6609	Gradient compression bandaging supply, not otherwise specified
Medical and Surgical Supplies	A6610	Gradient compression stocking, below knee, 18-30 mmhg, custom, each
Medical and Surgical Supplies	A7023	Mechanical allergen particle barrier/inhalation filter, cream, nasal, topical

Administrative, Miscellaneous and Investigational

Administrative, Miscellaneous and Investigational	A9608	Flotufolastat f 18, diagnostic, 1 millicurie
Administrative, Miscellaneous and Investigational	A9609	Fludeoxyglucose f18 up to 15 millicuries

Outpatient PPS

Outpatient PPS	C1600	Catheter, transluminal intravascular lesion preparation device, bladed, sheathed (insertable)
Outpatient PPS	C1601	Endoscope, single-use (i.e. disposable), pulmonary, imaging/illumination device (insertable)
Outpatient PPS	C1602	Orthopedic/device/drug matrix/absorbable bone void filler, antimicrobial-eluting (implantable)
Outpatient PPS	C1603	Retrieval device, insertable, laser (used to retrieve intravascular inferior vena cava filter)
Outpatient PPS	C1604	Graft, transmural transvenous arterial bypass (implantable), with all delivery system components
Outpatient PPS	C7556	Bronchoscopy, rigid or flexible, with bronchial alveolar lavage and transendoscopic endobronchial ultrasound (ebus) during bronchoscopic diagnostic or therapeutic intervention(s) for peripheral lesion(s), including fluoroscopic guidance, when performed
Outpatient PPS	C7557	Catheter placement in coronary artery(s) for coronary angiography, including intraprocedural injection(s) for coronary angiography, imaging supervision and interpretation with left heart catheterization including intraprocedural injection(s) for left ventriculography, when performed and intraprocedural coronary fractional flow reserve (ffr) with 3d functional mapping of color-coded ffr values for the coronary tree, derived from coronary angiogram data, for real-time review and interpretation of possible atherosclerotic stenosis(es) intervention
Outpatient PPS	C7558	Catheter placement in coronary artery(s) for coronary angiography, including intraprocedural injection(s) for coronary angiography, imaging supervision and interpretation with right and left heart catheterization including intraprocedural injection(s) for left ventriculography, when performed, catheter placement(s) in bypass graft(s) (internal mammary, free arterial, venous grafts) with bypass graft angiography with pharmacologic agent administration (eg, inhaled nitric oxide, intravenous infusion of nitroprusside, dobutamine, milrinone, or other agent) including assessing hemodynamic measurements before, during, after and repeat pharmacologic agent administration, when performed

Speciality	HCPCS Code	Description
Outpatient PPS	C7560	Endoscopic retrograde cholangiopancreatography (ercp) with removal of foreign body(s) or stent(s) from biliary/ pancreatic duct(s) and endoscopic cannulation of papilla with direct visualization of pancreatic/common bile duct(s)
Outpatient PPS	C7561	Debridement, bone (includes epidermis, dermis, subcutaneous tissue, muscle and/or fascia, if performed); first 20 sq cm or less with manual preparation and insertion of drug-delivery device(s), deep (e.g., subfascial)
Outpatient PPS	C7903	Group psychotherapy service for diagnosis, evaluation, or treatment of a mental health or substance use disorder provided remotely by hospital staff who are licensed to provide mental health services under applicable state law(s), when the patient is in their home, and there is no associated professional service
Outpatient PPS	C9159	Injection, prothrombin complex concentrate (human), balfaxar, per i.u. of factor ix activity
Outpatient PPS	C9160	Injection, daxibotulinumtoxina-lanm, 1 unit
Outpatient PPS	C9161	Injection, aflibercept hd, 1 mg
Outpatient PPS	C9162	Injection, avacincaptad pegol, 0.1 mg
Outpatient PPS	C9163	Injection, talquetamab-tgvs, 0.25 mg
Outpatient PPS	C9164	Cantharidin for topical administration, 0.7%, single unit dose applicator (3.2 mg)
Outpatient PPS	C9165	Injection, elranatamab-bcmm, 1 mg
Outpatient PPS	C9793	3d predictive model generation for pre-planning of a cardiac procedure, using data from cardiac computed tomographic angiography with report
Outpatient PPS	C9794	Therapeutic radiology simulation-aided field setting; complex, including acquisition of pet and ct imaging data required for radiopharmaceutical-directed radiation therapy treatment planning (i.e., modeling)
Outpatient PPS	C9795	Stereotactic body radiation therapy, treatment delivery, per fraction to 1 or more lesions, including image guidance and real-time positron emissions-based delivery adjustments to 1 or more lesions, entire course not to exceed 5 fractions

Durable Medical Equipment

Durable Medical Equipment	E0492	Power source and control electronics unit for oral device/appliance for neuromuscular electrical stimulation of the tongue muscle, controlled by phone application
Durable Medical Equipment	E0493	Oral device/appliance for neuromuscular electrical stimulation of the tongue muscle, used in conjunction with the power source and control electronics unit, controlled by phone application, 90-day supply
Durable Medical Equipment	E0530	Electronic positional obstructive sleep apnea treatment, with sensor, includes all components and accessories, any type
Durable Medical Equipment	E0678	Non-pneumatic sequential compression garment, full leg
Durable Medical Equipment	E0679	Non-pneumatic sequential compression garment, half leg
Durable Medical Equipment	E0680	Non-pneumatic compression controller with sequential calibrated gradient pressure
Durable Medical Equipment	E0681	Non-pneumatic compression controller without calibrated gradient pressure
Durable Medical Equipment	E0682	Non-pneumatic sequential compression garment, full arm
Durable Medical Equipment	E0732	Cranial electrotherapy stimulation (ces) system, any type
Durable Medical Equipment	E0733	Transcutaneous electrical nerve stimulator for electrical stimulation of the trigeminal nerve
Durable Medical Equipment	E0734	External upper limb tremor stimulator of the peripheral nerves of the wrist
Durable Medical Equipment	E0735	Non-invasive vagus nerve stimulator
Durable Medical Equipment	E1301	Whirlpool tub, walk-in, portable
Durable Medical Equipment	E2001	Suction pump, home model, portable or stationary, electric, any type, for use with external urine management system
Durable Medical Equipment	E3000	Speech volume modulation system, any type, including all components and accessories

Procedures / Professional Services

Procedures / Professional Svc	G0011	Individual counseling for pre-exposure prophylaxis (prep) by physician or qualified health care professional (qhp )to prevent human immunodeficiency virus (hiv), includes hiv risk assessment (initial or continued assessment of risk), hiv risk reduction and medication adherence, 15-30 minutes
Procedures / Professional Svc	G0012	Injection of pre-exposure prophylaxis (prep) drug for hiv prevention, under skin or into muscle
Procedures / Professional Svc	G0013	Individual counseling for pre-exposure prophylaxis (prep) by clinical staff to prevent human immunodeficiency virus (hiv), includes: hiv risk assessment (initial or continued assessment of risk), hiv risk reduction and medication adherence
Procedures / Professional Svc	G0017	Psychotherapy for crisis furnished in an applicable site of service (any place of service at which the non-facility rate for psychotherapy for crisis services applies, other than the office setting); first 60 minutes
Procedures / Professional Svc	G0018	Psychotherapy for crisis furnished in an applicable site of service (any place of service at which the non-facility rate for psychotherapy for crisis services applies, other than the office setting); each additional 30 minutes (list separately in addition to code for primary service)

Speciality	HCPCS Code	Description
Procedures / Professional Svc	G0019	Community health integration services performed by certified or trained auxiliary personnel, including a community health worker, under the direction of a physician or other practitioner; 60 minutes per calendar month, in the following activities to address social determinants of health (sdoh) need(s) that are significantly limiting the ability to diagnose or treat problem(s) addressed in an initiating visit: person-centered assessment, performed to better understand the individualized context of the intersection between the sdoh need(s) and the problem(s) addressed in the initiating visit. ++ conducting a person-centered assessment to understand patient's life story, strengths, needs, goals, preferences and desired outcomes, including understanding cultural and linguistic factors and including unmet sdoh needs (that are not separately billed). ++ facilitating patient-driven goal-setting and establishing an action plan. ++ providing tailored support to the patient as needed to accomplish the practitioner's treatment plan. practitioner, home-, and community- based care coordination. ++ coordinating receipt of needed services from healthcare practitioners, providers, and facilities; and from home- and community-based service providers, social service providers, and caregiver (if applicable). ++ communication with practitioners, home- and community-based service providers, hospitals, and skilled nursing facilities (or other health care facilities) regarding the patient's psychosocial strengths and needs, functional deficits, goals, preferences, and desired outcomes, including cultural and linguistic factors. ++ coordination of care transitions between and among health care practitioners and settings, including transitions involving referral to other clinicians; follow-up after an emergency department visit; or follow-up after discharges from hospitals, skilled nursing facilities or other health care facilities. ++ facilitating access to community-based social services (e.g., housing, utilities, transportation, food assistance) to address the sdoh need(s). health education- helping the patient contextualize health education provided by the patient's treatment team with the patient's individual needs, goals, and preferences, in the context of the sdoh need(s), and educating the patient on how to best participate in medical decision-making. building patient self-advocacy skills, so that the patient can interact with members of the health care team and related community-based services addressing the sdoh need(s), in ways that are more likely to promote personalized and effective diagnosis or treatment. health care access / health system navigation. ++ helping the patient access healthcare, including identifying appropriate practitioners or providers for clinical care and helping secure appointments with them. facilitating behavioral change as necessary for meeting diagnosis and treatment goals, including promoting patient motivation to participate in care and reach person-centered diagnosis or treatment goals. facilitating and providing social and emotional support to help the patient cope with the problem(s) addressed in the initiating visit, the sdoh need(s), and adjust daily routines to better meet diagnosis and treatment goals. leveraging lived experience when applicable to provide support, mentorship, or inspiration to meet treatment goals
Procedures / Professional Svc	G0022	Community health integration services, each additional 30 minutes per calendar month (list separately in addition to g0019)
Procedures / Professional Svc	G0023	Principal illness navigation services by certified or trained auxiliary personnel under the direction of a physician or other practitioner, including a patient navigator; 60 minutes per calendar month, in the following activities: person- centered assessment, performed to better understand the individual context of the serious, high-risk condition. ++ conducting a person-centered assessment to understand the patient's life story, strengths, needs, goals, preferences, and desired outcomes, including understanding cultural and linguistic factors and including unmet sdoh needs (that are not separately billed). ++ facilitating patient-driven goal setting and establishing an action plan. ++ providing tailored support as needed to accomplish the practitioner's treatment plan. identifying or referring patient (and caregiver or family, if applicable) to appropriate supportive services. practitioner, home, and community-based care coordination. ++ coordinating receipt of needed services from healthcare practitioners, providers, and facilities; home- and community- based service providers; and caregiver (if applicable). ++ communication with practitioners, home-, and community- based service providers, hospitals, and skilled nursing facilities (or other health care facilities) regarding the patient's psychosocial strengths and needs, functional deficits, goals, preferences, and desired outcomes, including cultural and linguistic factors. ++ coordination of care transitions between and among health care practitioners and settings, including transitions involving referral to other clinicians; follow-up after an emergency department visit; or follow- up after discharges from hospitals, skilled nursing facilities or other health care facilities. ++ facilitating access to community-based social services (e.g., housing, utilities, transportation, likely to promote personalized and effective treatment of their condition. health care access / health system navigation. ++ helping the patient access healthcare, including identifying appropriate practitioners or providers for clinical care, and helping secure appointments with them. ++ providing the patient with information/resources to consider participation in clinical trials or clinical research as applicable. facilitating behavioral change as necessary for meeting diagnosis and treatment goals, including promoting patient motivation to participate in care and reach person-centered diagnosis or treatment goals. facilitating and providing social and emotional support to help the patient cope with the condition, sdoh need(s), and adjust daily routines to better meet diagnosis and treatment goals. leverage knowledge of the serious, high-risk condition and/or lived experience when applicable to provide support, mentorship, or inspiration to meet treatment goals
Procedures / Professional Svc	G0024	Principal illness navigation services, additional 30 minutes per calendar month (list separately in addition to g0023)
Procedures / Professional Svc	G0136	Administration of a standardized, evidence-based social determinants of health risk assessment tool, 5-15 minutes
Procedures / Professional Svc	G0137	Intensive outpatient services; weekly bundle, minimum of 9 services over a 7 contiguous day period, which can include individual and group therapy with physicians or psychologists (or other mental health professionals to the extent authorized under state law); occupational therapy requiring the skills of a qualified occupational therapist; services of social workers, trained psychiatric nurses, and other staff trained to work with psychiatric patients; individualized activity therapies that are not primarily recreational or diversionary; family counseling (the primary purpose of which is treatment of the individual's condition); patient training and education (to the extent that training and educational activities are closely and clearly related to individual's care and treatment); diagnostic services; and such other items and services (excluding meals and transportation) that are reasonable and necessary for the diagnosis or active treatment of the individual's condition, reasonably expected to improve or maintain the individual's condition and functional level and to prevent relapse or hospitalization, and furnished pursuant to such guidelines relating to frequency and duration of services in accordance with a physician certification and plan of treatment (provision of the services by a medicare- enrolled opioid treatment program); list separately in addition to code for primary procedure

Speciality

HCPCS Code

Description

Procedures / Professional Svc

G0140

Principal illness navigation – peer support by certified or trained auxiliary personnel under the direction of a physician or other practitioner, including a certified peer specialist; 60 minutes per calendar month, in the following activities: person-centered interview, performed to better understand the individual context of the serious, high-risk condition. ++ conducting a person-centered interview to understand the patient's life story, strengths, needs, goals, preferences, and desired outcomes, including understanding cultural and linguistic factors, and including unmet sdoh needs (that are not

billed separately). ++ facilitating patient-driven goal setting and establishing an action plan. ++ providing tailored support as needed to accomplish the person-centered goals in the practitioner's treatment plan. identifying or referring patient (and caregiver or family, if applicable) to appropriate supportive services. practitioner, home, and community-based care communication. ++ assist the patient in communicating with their practitioners, home-, and community-based service providers, hospitals, and skilled nursing facilities (or other health care facilities) regarding the patient's psychosocial strengths and needs, goals, preferences, and desired outcomes, including cultural and linguistic factors. ++ facilitating access to community-based social services (e.g., housing, utilities, transportation, food assistance) as needed to address sdoh need(s). health education. helping the patient contextualize health education provided by the patient's treatment team with the patient's individual needs, goals, preferences, and sdoh need(s), and educating the patient (and caregiver if applicable) on how to best participate in medical decision-making. building patient self-advocacy skills, so that the patient can interact with members of the health care team and related community-based services (as needed), in ways that are more likely to promote personalized and effective treatment of their condition. developing and proposing strategies to help meet person-centered treatment goals and supporting the patient in using chosen strategies to reach person-centered treatment goals. facilitating and providing social and emotional support to help the patient cope with the condition, sdoh need(s), and adjust daily routines to better meet person-centered diagnosis and treatment goals. leverage knowledge of the serious, high-risk condition and/or lived experience when applicable to provide support, mentorship, or inspiration to meet treatment goals

Procedures / Professional Svc

G0146

Principal illness navigation – peer support, additional 30 minutes per calendar month (list separately in addition to g0140)

Drugs Administered Other than Oral Method

Drugs Administered Other than Oral Method	J0184	Injection, amisulpride, 1 mg
Drugs Administered Other than Oral Method	J0217	Injection, velmanase alfa-tycv, 1 mg
Drugs Administered Other than Oral Method	J0391	Injection, artesunate, 1 mg
Drugs Administered Other than Oral Method	J0402	Injection, aripiprazole (abilify asimtufii), 1 mg
Drugs Administered Other than Oral Method	J0576	Injection, buprenorphine extended-release (brixadi), 1 mg
Drugs Administered Other than Oral Method	J0688	Injection, cefazolin sodium (hikma), not therapeutically equivalent to j0690, 500 mg
Drugs Administered Other than Oral Method	J0750	Emtricitabine 200mg and tenofovir disoproxil fumarate 300mg, oral, fda approved prescription, only for use as hiv pre- exposure prophylaxis (not for use as treatment of hiv)
Drugs Administered Other than Oral Method	J0751	Emtricitabine 200mg and tenofovir alafenamide 25mg, oral, fda approved prescription, only for use as hiv pre-exposure prophylaxis (not for use as treatment of hiv)
Drugs Administered Other than Oral Method	J0799	Fda approved prescription drug, only for use as hiv pre-exposure prophylaxis (not for use as treatment of hiv), not otherwise classified
Drugs Administered Other than Oral Method	J0873	Injection, daptomycin (xellia) not therapeutically equivalent to j0878, 1 mg
Drugs Administered Other than Oral Method	J1105	Dexmedetomidine, oral, 1 mcg
Drugs Administered Other than Oral Method	J1246	Injection, dinutuximab, 0.1 mg
Drugs Administered Other than Oral Method	J1304	Injection, tofersen, 1 mg
Drugs Administered Other than Oral Method	J1412	Injection, valoctocogene roxaparvovec-rvox, per ml, containing nominal 2 x 10^13 vector genomes
Drugs Administered Other than Oral Method	J1413	Injection, delandistrogene moxeparvovec-rokl, per therapeutic dose
Drugs Administered Other than Oral Method	J1596	Injection, glycopyrrolate, 0.1 mg
Drugs Administered Other than Oral Method	J1939	Injection, bumetanide, 0.5 mg
Drugs Administered Other than Oral Method	J2404	Injection, nicardipine, 0.1 mg
Drugs Administered Other than Oral Method	J2508	Injection, pegunigalsidase alfa-iwxj, 1 mg
Drugs Administered Other than Oral Method	J2679	Injection, fluphenazine hcl, 1.25 mg

Speciality	HCPCS Code	Description
Drugs Administered Other than Oral Method	J2799	Injection, risperidone (uzedy), 1 mg
Drugs Administered Other than Oral Method	J3401	Beremagene geperpavec-svdt for topical administration, containing nominal 5 x 10^9 pfu/ml vector genomes, per 0.1 ml
Drugs Administered Other than Oral Method	J3425	Injection, hydroxocobalamin, 10 mcg

Chemotherapy Drugs

Chemotherapy Drugs	J9052	Injection, carmustine (accord), not therapeutically equivalent to j9050, 100 mg
Chemotherapy Drugs	J9072	Injection, cyclophosphamide, (dr. reddy's), 5 mg
Chemotherapy Drugs	J9172	Injection, docetaxel (ingenus) not therapeutically equivalent to j9171, 1 mg
Chemotherapy Drugs	J9255	Injection, methotrexate (accord) not therapeutically equivalent to j9250 and j9260, 50 mg
Chemotherapy Drugs	J9258	Injection, paclitaxel protein-bound particles (teva) not therapeutically equivalent to j9264, 1 mg
Chemotherapy Drugs	J9286	Injection, glofitamab-gxbm, 2.5 mg
Chemotherapy Drugs	J9321	Injection, epcoritamab-bysp, 0.16 mg
Chemotherapy Drugs	J9324	Injection, pemetrexed (pemrydi rtu), 10 mg
Chemotherapy Drugs	J9333	Injection, rozanolixizumab-noli, 1 mg
Chemotherapy Drugs	J9334	Injection, efgartigimod alfa, 2 mg and hyaluronidase-qvfc

Orthotic Procedures and Services

Orthotic Procedures and services

L3161

Foot, adductus positioning device, adjustable

Prosthetic Procedures

Prosthetic Procedures	L5615	Addition, endoskeletal knee-shin system, 4 bar linkage or multiaxial, fluid swing and stance phase control
Prosthetic Procedures	L5926	Addition to lower extremity prosthesis, endoskeletal, knee disarticulation, above knee, hip disarticulation, positional rotation unit, any type

Other Services

Other Services	M1211	Most recent hemoglobin a1c level > 9.0%
Other Services	M1212	Hemoglobin a1c level is missing, or was not performed during the measurement period (12 months)
Other Services	M1213	No history of spirometry results with confirmed airflow obstruction (fev1/fvc < 70%) and present spirometry is >= 70%
Other Services	M1214	Spirometry results with confirmed airflow obstruction (fev1/fvc < 70%) documented and reviewed
Other Services	M1215	Documentation of medical reason(s) for not documenting and reviewing spirometry results (e.g., patients with dementia or tracheostomy)
Other Services	M1216	No spirometry results with confirmed airflow obstruction (fev1/fvc < 70%) documented and/or no spirometry performed with results documented during the encounter
Other Services	M1217	Documentation of system reason(s) for not documenting and reviewing spirometry results (e.g., spirometry equipment not available at the time of the encounter)
Other Services	M1218	Patient has copd symptoms (e.g., dyspnea, cough/sputum, wheezing)
Other Services	M1219	Anaphylaxis due to the vaccine on or before the date of the encounter
Other Services	M1220	Dilated retinal eye exam with interpretation by an ophthalmologist or optometrist or artificial intelligence (ai) interpretation documented and reviewed; with evidence of retinopathy
Other Services	M1221	Dilated retinal eye exam with interpretation by an ophthalmologist or optometrist or artificial intelligence (ai) interpretation documented and reviewed; without evidence of retinopathy
Other Services	M1222	Glaucoma plan of care not documented, reason not otherwise specified
Other Services	M1223	Glaucoma plan of care documented
Other Services	M1224	Intraocular pressure (iop) reduced by a value less than 20% from the pre-intervention level
Other Services	M1225	Intraocular pressure (iop) reduced by a value of greater than or equal to 20% from the pre-intervention level
Other Services	M1226	Iop measurement not documented, reason not otherwise specified
Other Services	M1227	Evidence-based therapy was prescribed
Other Services	M1228	Patient, who has a reactive hcv antibody test, and has a follow up hcv viral test that detected hcv viremia, has hcv treatment initiated within 3 months of the reactive hcv antibody test
Other Services	M1229	Patient, who has a reactive hcv antibody test, and has a follow up hcv viral test that detected hcv viremia, is referred within 1 month of the reactive hcv antibody test to a clinician who treats hcv infection

Speciality	HCPCS Code	Description
Other Services	M1230	Patient has a reactive hcv antibody test and does not have a follow up hcv viral test, or patient has a reactive hcv antibody test and has a follow up hcv viral test that detects hcv viremia and is not referred to a clinician who treats hcv infection within 1 month and does not have hcv treatment initiated within 3 months of the reactive hcv antibody test, reason not given
Other Services	M1231	Patient receives hcv antibody test with nonreactive result
Other Services	M1232	Patient receives hcv antibody test with reactive result
Other Services	M1233	Patient does not receive hcv antibody test or patient does receive hcv antibody test but results not documented, reason not given
Other Services	M1234	Patient has a reactive hcv antibody test, and has a follow up hcv viral test that does not detect hcv viremia
Other Services	M1235	Documentation or patient report of hcv antibody test or hcv rna test which occurred prior to the performance period
Other Services	M1236	Baseline mrs > 2
Other Services	M1237	Patient reason for not screening for food insecurity, housing instability, transportation needs, utility difficulties, and interpersonal safety (e.g., patient declined or other patient reasons)
Other Services	M1238	Documentation that administration of second recombinant zoster vaccine could not occur during the performance period due to the recommended 2-6 month interval between doses (i.e, first dose received after october 31)
Other Services	M1239	Patient did not respond to the question of patient felt heard and understood by this provider and team
Other Services	M1240	Patient did not respond to the question of patient felt this provider and team put my best interests first when making recommendations about my care
Other Services	M1241	Patient did not respond to the question of patient felt this provider and team saw me as a person, not just someone with a medical problem
Other Services	M1242	Patient did not respond to the question of patient felt this provider and team understood what is important to me in my life
Other Services	M1243	Patient provided a response other than "completely true" for the question of patient felt heard and understood by this provider and team
Other Services	M1244	Patient provided a response other than "completely true" for the question of patient felt this provider and team put my best interests first when making recommendations about my care
Other Services	M1245	Patient provided a response other than "completely true" for the question of patient felt this provider and team saw me as a person, not just someone with a medical problem
Other Services	M1246	Patient provided a response other than "completely true" for the question of patient felt this provider and team understood what is important to me in my life
Other Services	M1247	Patient responded "completely true" for the question of patient felt this provider and team put my best interests first when making recommendations about my care
Other Services	M1248	Patient responded "completely true" for the question of patient felt this provider and team saw me as a person, not just someone with a medical problem
Other Services	M1249	Patient responded "completely true" for the question of patient felt this provider and team understood what is important to me in my life
Other Services	M1250	Patient responded as "completely true" for the question of patient felt heard and understood by this provider and team
Other Services	M1251	Patients for whom a proxy completed the entire hu survey on their behalf for any reason (no patient involvement)
Other Services	M1252	Patients who did not complete at least one of the four patient experience hu survey items and return the hu survey within 60 days of the ambulatory palliative care visit
Other Services	M1253	Patients who respond on the patient experience hu survey that they did not receive care by the listed ambulatory palliative care provider in the last 60 days (disavowal)
Other Services	M1254	Patients who were deceased when the hu survey reached them
Other Services	M1255	Patients who have another reason for visiting the clinic [not prenatal or postpartum care] and have a positive pregnancy test but have not established the clinic as an ob provider (e.g., plan to terminate the pregnancy or seek prenatal services elsewhere)
Other Services	M1256	Prior history of known cvd
Other Services	M1257	Cvd risk assessment not performed or incomplete (e.g., cvd risk assessment was not documented), reason not otherwise specified
Other Services	M1258	Cvd risk assessment performed, have a documented calculated risk score
Other Services	M1259	Patients listed on the kidney-pancreas transplant waitlist or who received a living donor transplant within the first year following initiation of dialysis
Other Services	M1260	Patients who were not listed on the kidney-pancreas transplant waitlist or patients who did not receive a living donor transplant within the first year following initiation of dialysis
Other Services	M1261	Patients that were on the kidney or kidney-pancreas waitlist prior to initiation of dialysis
Other Services	M1262	Patients who had a transplant prior to initiation of dialysis
Other Services	M1263	Patients in hospice on their initiation of dialysis date or during the month of evaluation
Other Services	M1264	Patients age 75 or older on their initiation of dialysis date

Speciality	HCPCS Code	Description
Other Services	M1265	Cms medical evidence form 2728 for dialysis patients: initial form completed
Other Services	M1266	Patients admitted to a skilled nursing facility (snf)
Other Services	M1267	Patients not on any kidney or kidney-pancreas transplant waitlist or is not in active status on any kidney or kidney- pancreas transplant waitlist as of the last day of each month during the measurement period
Other Services	M1268	Patients on active status on any kidney or kidney-pancreas transplant waitlist as of the last day of each month during the measurement period
Other Services	M1269	Receiving esrd mcp dialysis services by the provider on the last day of the reporting month
Other Services	M1270	Patients not on any kidney or kidney-pancreas transplant waitlist as of the last day of each month during the measurement period
Other Services	M1271	Patients with dementia at any time prior to or during the month
Other Services	M1272	Patients on any kidney or kidney-pancreas transplant waitlist as of the last day of each month during the measurement period
Other Services	M1273	Patients who were admitted to a skilled nursing facility (snf) within one year of dialysis initiation according to the cms-2728 form
Other Services	M1274	Patients who were admitted to a skilled nursing facility (snf) during the month of evaluation were excluded from that month
Other Services	M1275	Patients determined to be in hospice were excluded from month of evaluation and the remainder of reporting period
Other Services	M1276	Bmi documented outside normal parameters, no follow-up plan documented, no reason given
Other Services	M1277	Colorectal cancer screening results documented and reviewed
Other Services	M1278	Elevated or hypertensive blood pressure reading documented, and the indicated follow-up is documented
Other Services	M1279	Elevated or hypertensive blood pressure reading documented, indicated follow-up not documented, reason not given
Other Services	M1280	Women who had a bilateral mastectomy or who have a history of a bilateral mastectomy or for whom there is evidence of a right and a left unilateral mastectomy
Other Services	M1281	Blood pressure reading not documented, reason not given
Other Services	M1282	Patient screened for tobacco use and identified as a tobacco non-user
Other Services	M1283	Patient screened for tobacco use and identified as a tobacco user
Other Services	M1284	Patients age 66 or older in institutional special needs plans (snp) or residing in long term care with pos code 32, 33, 34, 54, or 56 for more than 90 consecutive days during the measurement period
Other Services	M1285	Screening, diagnostic, film, digital or digital breast tomosynthesis (3d) mammography results were not documented and reviewed, reason not otherwise specified
Other Services	M1286	Bmi is documented as being outside of normal parameters, follow-up plan is not completed for documented medical reason
Other Services	M1287	Bmi is documented below normal parameters and a follow-up plan is documented
Other Services	M1288	Documented reason for not screening or recommending a follow-up for high blood pressure
Other Services	M1289	Patient identified as tobacco user did not receive tobacco cessation intervention during the measurement period or in the six months prior to the measurement period (counseling and/or pharmacotherapy)
Other Services	M1290	Patient not eligible due to active diagnosis of hypertension
Other Services	M1291	Patients 66 years of age and older with at least one claim/encounter for frailty during the measurement period and a dispensed medication for dementia during the measurement period or the year prior to the measurement period
Other Services	M1292	Patients 66 years of age and older with at least one claim/encounter for frailty during the measurement period and either one acute inpatient encounter with a diagnosis of advanced illness or two outpatient, observation, ed or nonacute inpatient encounters on different dates of service with an advanced illness diagnosis during the measurement period or the year prior to the measurement period
Other Services	M1293	Bmi is documented above normal parameters and a follow-up plan is documented
Other Services	M1294